1-(2-Fluorophenyl)acetone

Basic Information

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CAS Number

2836-82-0

Molecular Formula

C9H9FO

Molecular Weight

152.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

47°C/0.05mmHg

Refractive Index

n20/D 1.4989(lit.)

SMILES

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CC(=O)CC1=CC=CC=C1F

InChI

InChI=1S/C9H9FO/c1-7(11)6-8-4-2-3-5-9(8)10/h2-5H,6H2,1H3

InChIKey

BANVZEUCJHUPOI-UHFFFAOYSA-N

LogP

1.9572

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

145

Safety Information

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GHS Hazard Pictograms

H227

Hazard Statement

H227 Combustible liquid
Flammable liquids

Synonyms & References

English

1-(2-Fluorophenyl)acetone #
MFCD00000325
A5391
2836-82-0
1-(2-fluorophenyl)propan-2-one
2-Propanone, (o-fluorophenyl)-
N11952
AKOS000215972
NS00049305
1-(2-Fluoro-phenyl)-propan-2-one
o-Fluorophenylacetone
EINECS 220-627-5
WLZ3564
EN300-157262
2-Fluorophenylacetone, 98%
F0970
2-Propanone, 1-(2-fluorophenyl)-
1-(2-Fluorophenyl)acetone
DTXSID10182604
FT-0605538
(2-Fluorophenyl)acetone, 99%
PD151209
(2-Fluorophenyl)acetone
1-(2-Fluorophenyl)-2-propanone
N4SU83BW94
PS-8921
Q-101900
2-fluorophenylacetone
SCHEMBL125583
CS-W008481
1-(2-Fluorophenyl)propan-2-one

MDL Number

MFCD00000325

Customs Code

2914700090

FAQ

What are the physical and chemical properties of 1-(2-Fluorophenyl)acetone (CAS: 2836-82-0)?

1-(2-Fluorophenyl)acetone (CAS: 2836-82-0) is a colorless to white crystalline solid with a molecular weight of approximately 166.13 g/mol. It is slightly soluble in water but miscible with most organic solvents. The compound is known for its reactivity with nucleophiles and electrophiles, making it a versatile intermediate in organic synthesis. It has a melting point of around 63-65°C and a boiling point of about 122-124°C. Its solubility in water is low, making it suitable for various chemical reactions.

How is 1-(2-Fluorophenyl)acetone (CAS: 2836-82-0) typically synthesized?

1-(2-Fluorophenyl)acetone can be synthesized through a Wittig reaction or a Friedel-Crafts acylation process. Commonly, the synthesis involves the reaction of benzaldehyde with phosphorus ylide (Wittig reagent) or acylation of 2-fluorophenol with acetyl chloride in the presence of a Lewis acid catalyst like aluminum chloride. The yield and selectivity of the reaction can be enhanced by optimizing conditions such as temperature, solvent, and catalyst type. This compound is often used as an intermediate in the production of Fluorophenyl derivatives for pharmaceuticals.

What industries use 1-(2-Fluorophenyl)acetone (CAS: 2836-82-0)?

1-(2-Fluorophenyl)acetone (CAS: 2836-82-0) is primarily used in the pharmaceutical industry for the synthesis of various fluorophenyl-containing compounds. It also finds applications in the production of polymers, specifically in the development of fluorinated polymers for biomedical and electronic applications. Additionally, it is used in the manufacturing of fluorinated sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 1-(2-Fluorophenyl)acetone (CAS: 2836-82-0)?

When handling 1-(2-Fluorophenyl)acetone (CAS: 2836-82-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a laboratory coat. This compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, it should be cleaned up immediately with appropriate absorbent materials. Proper ventilation is crucial during handling to prevent inhalation. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures. Handling should be conducted in a well-ventilated fume hood to minimize exposure.