1-(2-Fluorophenyl)acetone(CAS: 2836-82-0)

1-(2-Fluorophenyl)acetone (CAS: 2836-82-0) is a colorless to white crystalline solid with a molecular weight of approximately 166.13 g/mol. It is slightly soluble in water but miscible with most organic solvents. The compound is known for its reactivity with nucleophiles and electrophiles, making it a versatile intermediate in organic synthesis. It has a melting point of around 63-65°C and a boiling point of about 122-124°C. Its solubility in water is low, making it suitable for various chemical reactions.

1-(2-Fluorophenyl)acetone can be synthesized through a Wittig reaction or a Friedel-Crafts acylation process. Commonly, the synthesis involves the reaction of benzaldehyde with phosphorus ylide (Wittig reagent) or acylation of 2-fluorophenol with acetyl chloride in the presence of a Lewis acid catalyst like aluminum chloride. The yield and selectivity of the reaction can be enhanced by optimizing conditions such as temperature, solvent, and catalyst type. This compound is often used as an intermediate in the production of Fluorophenyl derivatives for pharmaceuticals.

1-(2-Fluorophenyl)acetone (CAS: 2836-82-0) is primarily used in the pharmaceutical industry for the synthesis of various fluorophenyl-containing compounds. It also finds applications in the production of polymers, specifically in the development of fluorinated polymers for biomedical and electronic applications. Additionally, it is used in the manufacturing of fluorinated sensors and semiconductors due to its unique chemical properties.

When handling 1-(2-Fluorophenyl)acetone (CAS: 2836-82-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a laboratory coat. This compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, it should be cleaned up immediately with appropriate absorbent materials. Proper ventilation is crucial during handling to prevent inhalation. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures. Handling should be conducted in a well-ventilated fume hood to minimize exposure.