Compound Q&A
How is 1-(2-Fluorophenyl)acetone (CAS: 2836-82-0) typically synthesized?
Answer
1-(2-Fluorophenyl)acetone can be synthesized through a Wittig reaction or a Friedel-Crafts acylation process. Commonly, the synthesis involves the reaction of benzaldehyde with phosphorus ylide (Wittig reagent) or acylation of 2-fluorophenol with acetyl chloride in the presence of a Lewis acid catalyst like aluminum chloride. The yield and selectivity of the reaction can be enhanced by optimizing conditions such as temperature, solvent, and catalyst type. This compound is often used as an intermediate in the production of Fluorophenyl derivatives for pharmaceuticals.
About
CAS No
2836-82-0
English Name
1-(2-Fluorophenyl)acetone
Molecular Formula
C9H9FO
Molecular Weight
152.17 g/mol
SMILES
CC(=O)CC1=CC=CC=C1F
InChIKey
BANVZEUCJHUPOI-UHFFFAOYSA-N
Last Updated: 2025-10-08 00:58
