Methyl 4-acetyl-2-hydroxybenzoate

Basic Information

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CAS Number

27475-11-2

Molecular Formula

C10H10O4

Molecular Weight

194.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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CC(=O)C1=CC(=C(C=C1)C(=O)OC)O

InChI

InChI=1S/C10H10O4/c1-6(11)7-3-4-8(9(12)5-7)10(13)14-2/h3-5,12H,1-2H3

InChIKey

ATVFLHHFBWGFDZ-UHFFFAOYSA-N

LogP

1.3814

Topological Polar Surface Area

63.599999999999994 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

236

Synonyms & References

English

27475-11-2
Methyl 4-acetyl-2-hydroxybenzoate
4-ACETYL-2-HYDROXY-BENZOIC ACID METHYLESTER
Methyl4-acetyl-2-hydroxybenzoate
C74425
AKOS006311786
AS-65743
SCHEMBL5082071
DTXSID00537003
MFCD09907817
CS-0158458
4-ACETYL-2-HYDROXY-BENZOIC ACID METHYL ESTER
Benzoic acid,4-acetyl-2-hydroxy-, methyl ester
methyl 4-acetylsalicylate
FCH876138
4-acetyl-2-hydroxybenzoic acid methyl ester

MDL Number

MFCD09907817

Customs Code

2918990090

FAQ

What are the physical and chemical properties of Methyl 4-acetyl-2-hydroxybenzoate (CAS: 27475-11-2)?

Methyl 4-acetyl-2-hydroxybenzoate (CAS: 27475-11-2) is a white to pale yellow crystalline solid with a molecular weight of approximately 218.22 g/mol. It is slightly soluble in water and soluble in organic solvents such as ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo ester hydrolysis under basic conditions. It is less reactive towards acid-catalyzed hydrolysis.

How is Methyl 4-acetyl-2-hydroxybenzoate (CAS: 27475-11-2) typically synthesized?

Methyl 4-acetyl-2-hydroxybenzoate (CAS: 27475-11-2) is typically synthesized via esterification of acetic anhydride and 4-hydroxybenzoic acid. The reaction is usually conducted in the presence of a catalyst such as sulfuric acid, and yields up to 90% of the desired product. The product can be purified by recrystallization from ethanol.

What industries use Methyl 4-acetyl-2-hydroxybenzoate (CAS: 27475-11-2)?

Methyl 4-acetyl-2-hydroxybenzoate (CAS: 27475-11-2) is used in the pharmaceutical industry for synthesizing intermediates and APIs, in the polymer industry as a plasticizer, and in the sensor industry for detecting specific compounds. It is also utilized in the semiconductor industry as a resist material in photolithography processes.

What precautions should be taken when handling Methyl 4-acetyl-2-hydroxybenzoate (CAS: 27475-11-2)?

When handling Methyl 4-acetyl-2-hydroxybenzoate (CAS: 27475-11-2), ensure the use of appropriate personal protective equipment (PPE) such as gloves and safety glasses. Work in a well-ventilated area or in a fume hood to minimize inhalation risk. In case of spill, neutralize any acid present and dispose of the material according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.