Methyl 2-(dimethoxyphosphoryl)propanoate

Basic Information

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CAS Number

26530-60-9

Molecular Formula

C6H13O5P

Molecular Weight

196.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Agricultural Chemicals Pesticides Insecticides

Basic Physical Properties

Boiling Point

140 ºC (18 Torr)

Flash Point

116.5±42.9 ºC,

Refractive Index

1.4377 (589.3 nm 20 ºC)

SMILES

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CC(C(=O)OC)P(=O)(OC)OC

InChI

InChI=1S/C6H13O5P/c1-5(6(7)9-2)12(8,10-3)11-4/h5H,1-4H3

InChIKey

STYUEUAAPQZSTL-UHFFFAOYSA-N

LogP

1.0337999999999998

Topological Polar Surface Area

61.83000000000001 Å²

Hydrogen Bond Donor/Acceptor

0 / 5

Complexity

194

Synonyms & References

English

Propanoic acid, 2-(dimethoxyphosphinyl)-, methyl ester
dimethyl [1-(methoxycarbonyl)ethyl]phosphonate
Methyl 2-(dimethoxyphosphoryl)propanoate
.dimethyl 1-methoxycarbonylethyl phosphonate
.trimethyl
Methyl 2-(Dimethoxyphosphoryl)propionate
Trimethyl 2-phosphonopropionate
Trimethyl alpha-phosphonopropionate
Methyl 2-dimethoxyphosphorylpropanoate
SCHEMBL2978531
Dimethyl [1-(methoxycarbonyl)ethyl]phosphonate
MFCD21607028
26530-60-9
Propanoic acid, (dimethoxyphosphinyl)-, methyl ester
AKOS025287510
F18252
SY032623
Methyl dimethylphosphonopropanoate
DB-109159
BBA53060
Methyl2-(dimethoxyphosphoryl)propanoate

MDL Number

MFCD21607028

FAQ

What are the physical and chemical properties of Methyl 2-(dimethoxyphosphoryl)propanoate (CAS: 26530-60-9)?

Methyl 2-(dimethoxyphosphoryl)propanoate is a colorless liquid with a molecular weight of approximately 218.2 g/mol. It has a high solubility in organic solvents and is less soluble in water. This compound exhibits strong reactivity towards nucleophiles and generates phosphoric acid derivatives. It crystallizes in the form of hexahydrate with a melting point of about 40°C.

How is Methyl 2-(dimethoxyphosphoryl)propanoate (CAS: 26530-60-9) typically synthesized?

Methyl 2-(dimethoxyphosphoryl)propanoate is synthesized by the phosphorylation of methyl 2-methoxypropanoate with phosphorus oxychloride. The reaction is carried out under anhydrous conditions using a catalyst such as pyridine. The yield of the product is typically around 85%, and the reaction is selective towards the desired phosphorylation product.

What industries use Methyl 2-(dimethoxyphosphoryl)propanoate (CAS: 26530-60-9)?

Methyl 2-(dimethoxyphosphoryl)propanoate is used in pharmaceuticals for the synthesis of various phosphoramidites and other phosphorus-containing compounds. It is also utilized in polymer and sensor applications due to its ability to form stable phosphoric acid derivatives. Additionally, it is relevant in semiconductor manufacturing for specific etching and passivation processes.

What precautions should be taken when handling Methyl 2-(dimethoxyphosphoryl)propanoate (CAS: 26530-60-9)?

When handling Methyl 2-(dimethoxyphosphoryl)propanoate, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Laboratory operations should be conducted in a well-ventilated fume hood. In case of a spill, immediately contain the spill and clean it up using an appropriate absorbent material. For detailed safety information, refer to the Material Safety Data Sheet (MSDS) for CAS number 26530-60-9.