Methyl 2-(dimethoxyphosphoryl)propanoate(CAS: 26530-60-9)

Methyl 2-(dimethoxyphosphoryl)propanoate is a colorless liquid with a molecular weight of approximately 218.2 g/mol. It has a high solubility in organic solvents and is less soluble in water. This compound exhibits strong reactivity towards nucleophiles and generates phosphoric acid derivatives. It crystallizes in the form of hexahydrate with a melting point of about 40°C.

Methyl 2-(dimethoxyphosphoryl)propanoate is synthesized by the phosphorylation of methyl 2-methoxypropanoate with phosphorus oxychloride. The reaction is carried out under anhydrous conditions using a catalyst such as pyridine. The yield of the product is typically around 85%, and the reaction is selective towards the desired phosphorylation product.

Methyl 2-(dimethoxyphosphoryl)propanoate is used in pharmaceuticals for the synthesis of various phosphoramidites and other phosphorus-containing compounds. It is also utilized in polymer and sensor applications due to its ability to form stable phosphoric acid derivatives. Additionally, it is relevant in semiconductor manufacturing for specific etching and passivation processes.

When handling Methyl 2-(dimethoxyphosphoryl)propanoate, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Laboratory operations should be conducted in a well-ventilated fume hood. In case of a spill, immediately contain the spill and clean it up using an appropriate absorbent material. For detailed safety information, refer to the Material Safety Data Sheet (MSDS) for CAS number 26530-60-9.