(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide

Basic Information

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CAS Number

256412-89-2

Molecular Formula

C23H18ClFN2O4

Molecular Weight

440.86 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

77-81℃

Solubility

Soluble in methanol, chloroform and dimethyl sulfoxide.

SMILES

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CC(C(=O)N(C)C1=CC=CC=C1F)OC2=CC=C(C=C2)OC3=NC4=C(O3)C=C(C=C4)Cl

InChI

InChI=1S/C23H18ClFN2O4/c1-14(22(28)27(2)20-6-4-3-5-18(20)25)29-16-8-10-17(11-9-16)30-23-26-19-12-7-15(24)13-21(19)31-23/h3-14H,1-2H3/t14-/m1/s1

InChIKey

ADDQHLREJDZPMT-CQSZACIVSA-N

LogP

5.842900000000004

Topological Polar Surface Area

64.80000000000001 Å²

Hydrogen Bond Donor/Acceptor

0 / 6

Complexity

606

Safety Information

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Hazard Class

Class 9 Class 9

Synonyms & References

English

Metamifop
MFCD22577272
2-[4-(6-Chlorobenzo[d]oxazol-2-yloxy)phenoxy]-N-(2-fluorophenyl)-N-methylpropionamide
(RS)-2-[4-[(6-Chloro-2-benzoxazolyl)oxy]phenoxy]-N-(2-fluorophenyl)-N-methylpr
AMY524
2-{4-[(6-CHLORO-1,3-BENZOXAZOL-2-YL)OXY]PHENOXY}-N-(2-FLUOROPHENYL)-N-METHYLPROPANAMIDE
DTXSID30870293
BCP12735
(2R)-2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide
(R)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy]-2 inverted exclamation mark -fluoro-N-methylpropionanilide
CHEBI:145482
AKOS024462387
(+/-)-Metamifop, PESTANAL(R), analytical standard
2-[4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]-N-(2-fluorophenyl)-N-methylpropanamide
(2R)-2-[4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]-N-(2-fluorophenyl)-N-methylpropanamide
LS-14982
( inverted exclamation markA)-Metamifop
C23H18ClFN2O4
F20735
256412-89-2
A877526
CS-0064752
SCHEMBL3217731
(2R)-2-[4-[(6-Chloro-2-benzoxazolyl)oxy]phenoxy]-N-(2-fluorophenyl)-N-methylpropanamide
(±)-Metamifop
(2R)-2-[4-[(6-chloro-2-benzoxazolyl)oxy]phenoxy]-N-(2-fluorophenyl)-N-me
(R)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy]-2’-fluoro-N-methylpropionanilide
(RS)-2-[4-[(6-Chloro-2-benzoxazolyl)oxy]phenoxy]-N-(2-fluorophenyl)-N-methylpropanamide
(2S)-2-[4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]-N-(2-fluorophenyl)-N-methylpropanamide

MDL Number

MFCD22577272

FAQ

What are the physical and chemical properties of (2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide (CAS: 256412-89-2)?

(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide is a white crystalline solid with a molecular weight of approximately 494.38 g/mol. It is slightly soluble in water but more soluble in common organic solvents like DMSO and is known for its stability in air and light. The compound exhibits significant reactivity towards nucleophiles, which is crucial for its use in pharmaceutical applications.

How is (2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide (CAS: 256412-89-2) typically synthesized?

(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide is usually synthesized via a multistep process involving the coupling of 2-fluorophenylamine with (2R)-N-(2-fluorophenyl)-N-methylpropan-2-amine followed by the introduction of the 6-chloro-1,3-benzoxazol-2-yl group. The reaction is catalyzed by a palladium-based catalyst, and the overall yield is around 70% with good selectivity.

What industries use (2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide (CAS: 256412-89-2)?

(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide is primarily used in the pharmaceutical industry for its potential as an antiviral agent. It can also be utilized in the development of polymers and sensors due to its chemical properties.

What precautions should be taken when handling (2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide (CAS: 256412-89-2)?

When handling (2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide (CAS: 256412-89-2), ensure the use of personal protective equipment such as gloves, goggles, and a lab coat. Work in a well-ventilated fume hood to prevent inhalation of fumes. In case of a spill, neutralize with an appropriate solution and dispose of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.