(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide(CAS: 256412-89-2)

(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide is a white crystalline solid with a molecular weight of approximately 494.38 g/mol. It is slightly soluble in water but more soluble in common organic solvents like DMSO and is known for its stability in air and light. The compound exhibits significant reactivity towards nucleophiles, which is crucial for its use in pharmaceutical applications.

(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide is usually synthesized via a multistep process involving the coupling of 2-fluorophenylamine with (2R)-N-(2-fluorophenyl)-N-methylpropan-2-amine followed by the introduction of the 6-chloro-1,3-benzoxazol-2-yl group. The reaction is catalyzed by a palladium-based catalyst, and the overall yield is around 70% with good selectivity.

(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide is primarily used in the pharmaceutical industry for its potential as an antiviral agent. It can also be utilized in the development of polymers and sensors due to its chemical properties.

When handling (2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide (CAS: 256412-89-2), ensure the use of personal protective equipment such as gloves, goggles, and a lab coat. Work in a well-ventilated fume hood to prevent inhalation of fumes. In case of a spill, neutralize with an appropriate solution and dispose of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.