Compound Q&A
How is (2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide (CAS: 256412-89-2) typically synthesized?
Answer
![(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide](https://static.chemtradehub.com/structs/256/256412-89-2-7b2a.webp "(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide")
(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide is usually synthesized via a multistep process involving the coupling of 2-fluorophenylamine with (2R)-N-(2-fluorophenyl)-N-methylpropan-2-amine followed by the introduction of the 6-chloro-1,3-benzoxazol-2-yl group. The reaction is catalyzed by a palladium-based catalyst, and the overall yield is around 70% with good selectivity.
About
CAS No
256412-89-2
English Name
(2R)-2-{4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide
Molecular Formula
C23H18ClFN2O4
Molecular Weight
440.86 g/mol
SMILES
CC(C(=O)N(C)C1=CC=CC=C1F)OC2=CC=C(C=C2)OC3=NC4=C(O3)C=C(C=C4)Cl
InChIKey
ADDQHLREJDZPMT-CQSZACIVSA-N
Last Updated: 2025-09-19 21:14
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