Desonide 21-acetate

Basic Information

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CAS Number

25092-25-5

Molecular Formula

C26H34O7

Molecular Weight

458.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)(C)C

InChI

InChI=1S/C26H34O7/c1-14(27)31-13-20(30)26-21(32-23(2,3)33-26)11-18-17-7-6-15-10-16(28)8-9-24(15,4)22(17)19(29)12-25(18,26)5/h8-10,17-19,21-22,29H,6-7,11-13H2,1-5H3/t17-,18-,19-,21+,22+,24-,25-,26+/m0/s1

InChIKey

IMVOEOHIGCNVQW-SBOGIFMKSA-N

LogP

2.897500000000001

Topological Polar Surface Area

99.13000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

979

Synonyms & References

English

(Desonide-21-Acetate) 21-Acetoxy-11b-Hydroxy-16-alpha, 17-alpha-Isopropylidinedioxy-pregna-1,4-Diene-3, 20-Dione
11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide 21-acetate
Desonide 21-Acetate
2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-Hydroxy-6a,8a,10,10-tetramethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate
(11beta,16alpha)-21-(Acetyloxy)-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate
11b,21-Dihydroxy-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione-21-acetate
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(11b,16a)-
Pregna-1,4-diene-3,20-dione,11beta,16alpha,17alpha,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide 21-acetate
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-
SCHEMBL11321819
[2-[(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] acetate
PREGNA-1,4-DIENE-3,20-DIONE, 11.BETA.,16.ALPHA.,17,21-TETRAHYDROXY-, CYCLIC 16,17-ACETAL WITH ACETONE, 21-ACETATE
UNII-45JZL0UFSD
PREGNA-1,4-DIENE-3,20-DIONE, 21-(ACETYLOXY)-11-HYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (11.BETA.,16.ALPHA.)-
45JZL0UFSD
Desonide 21-acetate
25092-25-5
Q27258847
ACETYLDESONIDE [USP IMPURITY]

FAQ

What are the physical and chemical properties of Desonide 21-acetate (CAS: 25092-25-5)?

Desonide 21-acetate (CAS: 25092-25-5) is a crystalline compound with a molecular weight of approximately 418.5 g/mol. It has a melting point around 108-109°C and is slightly soluble in water. Chemically, it is reactive with strong bases and sensitive to moisture. It may undergo hydrolysis and degradation in aqueous environments.

How is Desonide 21-acetate (CAS: 25092-25-5) typically synthesized?

Desonide 21-acetate (CAS: 25092-25-5) is typically synthesized by acetylation of desonide, a steroidal compound, using acetic anhydride and a suitable base like sodium hydride under anhydrous conditions. The reaction yields a high purity product with a good yield of around 85%. The process requires careful control of temperature and reaction time to achieve the desired product.

What industries use Desonide 21-acetate (CAS: 25092-25-5)?

Desonide 21-acetate (CAS: 25092-25-5) is primarily used in pharmaceuticals, where it serves as a precursor in the synthesis of desonide, a corticosteroid used in topical dermatological treatments. It is also utilized in the polymer industry for its biological properties and in research applications due to its steroidal structure.

What precautions should be taken when handling Desonide 21-acetate (CAS: 25092-25-5)?

When handling Desonide 21-acetate (CAS: 25092-25-5), it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Handle in a fume hood to avoid inhalation risks. Store away from moisture and heat. In case of spill, neutralize with an appropriate absorbent and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information.