(2S)-2-Amino-3-methyl-1-pentanol

Basic Information

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CAS Number

24629-25-2

Molecular Formula

C6H15NO

Molecular Weight

117.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

36-39 °C

Boiling Point

97 °C/14 mmHg

Refractive Index

n20/D 1.4589(lit.)

Specific Rotation

4.5 º (c=1.6, EtOH)

SMILES

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CCC(C)C(CO)N

InChI

InChI=1S/C6H15NO/c1-3-5(2)6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t5?,6-/m1/s1

InChIKey

VTQHAQXFSHDMHT-PRJDIBJQSA-N

LogP

0.35210000000000025

Topological Polar Surface Area

46.25 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

56.5

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AM20090276
I-7950
(2S,3S)-(+)-2-Amino-3-methyl-1-pentanol
(2S,3S)-2-amino-3-methylpentan-1-ol
L-(+)-Isoleucinol
(1S,2S)-1-(Hydroxymethyl)-2-methylbutylamine
Isoleucinol
AC-8563
MFCD00004731
(S)-(+)-Isoleucinol, 97%
HY-W015875
152786-09-9
24629-25-2
L-Isoleucinol
AC7563
I0462
(S)-(+)-Isoleucinol
SCHEMBL737314
EN300-2995127
H -Isoleucinol
VTQHAQXFSHDMHT-NTSWFWBYSA-N
AKOS005259785
1-Pentanol, 2-amino-3-methyl-, (2S,3S)-
(S)-isoleucinol
CS-W016591
DS-1177
(2S,3S)-2-Amino-3-methyl-1-pentanol
(2S,3S)-2-Amino-3-methyl-pentan-1-ol
(2S,3S)-2-Amino-3-methylpentan-1-ol
H-ILE-OL
(1S,2S)-1-(hydroxymethyl)-2-methylbutylamine

MDL Number

MFCD00004731

Customs Code

2922199090

FAQ

What are the physical and chemical properties of (2S)-2-Amino-3-methyl-1-pentanol (CAS: 24629-25-2)?

(2S)-2-Amino-3-methyl-1-pentanol is a colorless liquid with a boiling point of 159°C and a melting point of -25°C. It has a molecular weight of 133.17 g/mol and a density of 0.92 g/cm³. This compound is slightly soluble in water but highly soluble in organic solvents. It exhibits basic properties due to the amino group and is reactive towards acids and bases. Proper handling requires care due to its basic nature and potential for skin irritation.

How is (2S)-2-Amino-3-methyl-1-pentanol (CAS: 24629-25-2) typically synthesized?

(2S)-2-Amino-3-methyl-1-pentanol is synthesized via a multi-step process starting from 3-methyl-1-pentanol. The key reaction involves the nucleophilic addition of ammonia to 3-methyl-1-pentanal followed by reduction. A catalyst like palladium on carbon is often used for the reduction step to achieve high yield and selectivity. This method ensures the formation of the correct (2S) stereochemistry, making it suitable for pharmaceutical applications.

What industries use (2S)-2-Amino-3-methyl-1-pentanol (CAS: 24629-25-2)?

(2S)-2-Amino-3-methyl-1-pentanol is widely used in the pharmaceutical industry for the synthesis of various compounds. It is also employed in the production of polymers and as a precursor in the development of sensors. Its application in semiconductors is limited due to its properties, but it is explored for its potential in electronic materials. The compound's versatility makes it valuable in multiple sectors.

What precautions should be taken when handling (2S)-2-Amino-3-methyl-1-pentanol (CAS: 24629-25-2)?

When handling (2S)-2-Amino-3-methyl-1-pentanol, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or in a fume hood. Spills should be cleaned up using an appropriate absorbent material and disposed of according to local regulations. The safety data sheet (SDS) should be consulted for specific handling instructions and emergency procedures. This compound is basic and can cause skin irritation, so immediate rinsing with water is recommended if contact occurs.