(2S)-2-Amino-3-methyl-1-pentanol(CAS: 24629-25-2)

(2S)-2-Amino-3-methyl-1-pentanol is a colorless liquid with a boiling point of 159°C and a melting point of -25°C. It has a molecular weight of 133.17 g/mol and a density of 0.92 g/cm³. This compound is slightly soluble in water but highly soluble in organic solvents. It exhibits basic properties due to the amino group and is reactive towards acids and bases. Proper handling requires care due to its basic nature and potential for skin irritation.

(2S)-2-Amino-3-methyl-1-pentanol is synthesized via a multi-step process starting from 3-methyl-1-pentanol. The key reaction involves the nucleophilic addition of ammonia to 3-methyl-1-pentanal followed by reduction. A catalyst like palladium on carbon is often used for the reduction step to achieve high yield and selectivity. This method ensures the formation of the correct (2S) stereochemistry, making it suitable for pharmaceutical applications.

(2S)-2-Amino-3-methyl-1-pentanol is widely used in the pharmaceutical industry for the synthesis of various compounds. It is also employed in the production of polymers and as a precursor in the development of sensors. Its application in semiconductors is limited due to its properties, but it is explored for its potential in electronic materials. The compound's versatility makes it valuable in multiple sectors.

When handling (2S)-2-Amino-3-methyl-1-pentanol, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or in a fume hood. Spills should be cleaned up using an appropriate absorbent material and disposed of according to local regulations. The safety data sheet (SDS) should be consulted for specific handling instructions and emergency procedures. This compound is basic and can cause skin irritation, so immediate rinsing with water is recommended if contact occurs.