4-(1-Pyrrolidinyl)pyridine

Basic Information

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CAS Number

2456-81-7

Molecular Formula

C9H12N2

Molecular Weight

148.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

56.0 to 61.0 deg-C

Boiling Point

170°C/12mmHg

Water Solubility

3 g/L (21 ºC)

Solubility

methanol: 0.1 g/mL, clear

Refractive Index

1.5378 (estimate)

SMILES

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C1CCN(C1)C2=CC=NC=C2

InChI

InChI=1S/C9H12N2/c1-2-8-11(7-1)9-3-5-10-6-4-9/h3-6H,1-2,7-8H2

InChIKey

RGUKYNXWOWSRET-UHFFFAOYSA-N

LogP

1.6818

Topological Polar Surface Area

16.130000000000003 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

113

Safety Information

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GHS Hazard Pictograms

H301

H314

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Synonyms & References

English

O11284
AM20050997
4-pyrrolidinylpyridine
4-pyrrollidinopyridine
BDBM50556494
4-(Pyrrolidin-1-yl)pyridine
FT-0619461
CHEMBL4754833
AC-20826
4-Pyrrolidinepyridine
Q229878
4 -pyrrolidinopyridine
4-pyrrolidin-1-yl-pyridine
4-(1-pyrrolidino)pyridine
4-pyrrolidin-1-ylpyridine
4-Pyrrolidinopyridine, 98%
2456-81-7
EN300-21369
4-Pyrrolidine-1-yl-pyridine
InChI=1/C9H12N2/c1-2-8-11(7-1)9-3-5-10-6-4-9/h3-6H,1-2,7-8H
Pyridine, 4-(1-pyrrolidinyl)-
CS-W008051
BP-20215
PS-4097
4-(1-pyrrolidinyl)-pyridine
EINECS 219-534-2
4-Pyrrolidinopyridine
1-(4-Pyridyl)pyrrolidine
W-107303
DH59VKG9S4
4-(1-Pyrrolidinyl)pyridin

MDL Number

MFCD00006415

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 4-(1-Pyrrolidinyl)pyridine (CAS: 2456-81-7)?

4-(1-Pyrrolidinyl)pyridine has a crystalline form and a molecular weight of approximately 178.25 g/mol. It is slightly soluble in water but readily soluble in organic solvents like methanol and ethanol. The compound exhibits basic properties and is reactive towards acidic media. It is stable under normal storage conditions but should be protected from moisture and light.

How is 4-(1-Pyrrolidinyl)pyridine (CAS: 2456-81-7) typically synthesized?

4-(1-Pyrrolidinyl)pyridine is commonly synthesized via the condensation of pyridine with 1-pyrrolidinecarboxylic acid, using an acid catalyst like hydrochloric acid. The reaction is typically carried out in an organic solvent such as ethanol. The yield is around 70-80%, and the product can be isolated by crystallization.

What industries use 4-(1-Pyrrolidinyl)pyridine (CAS: 2456-81-7)?

4-(1-Pyrrolidinyl)pyridine is used in the pharmaceutical industry for the preparation of certain drugs. It is also employed in the synthesis of dyes and pigments, and can be found in the production of organic electronic materials such as organic semiconductors. Additionally, it has applications in the development of sensors and as a precursor in polymer synthesis.

What precautions should be taken when handling 4-(1-Pyrrolidinyl)pyridine (CAS: 2456-81-7)?

When handling 4-(1-Pyrrolidinyl)pyridine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.