Isavuconazole | CAS No. 241479-67-4

Isavuconazole

Basic Information

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CAS Number

241479-67-4

Molecular Formula

C22H17F2N5OS

Molecular Weight

437.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

678°C at 760 mmHg

SMILES

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C[C@@H](c1nc(cs1)c2ccc(C#N)cc2)[C@](O)(Cn3cncn3)c4cc(F)ccc4F

InChI

1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1

InChIKey

DDFOUSQFMYRUQK-RCDICMHDSA-N

LogP

4.24298

Complexity

657

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Isavuconazole
4-[2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
Isavuconazol
Isavuconazonium
Bal4815
BAL-4815
FK463
Micafungin sodium
RO-0094815
UNII-60UTO373KE
4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile
BAL 4815
Isavuconazole [INN]
60UTO373KE
RO 0094815
Isavuconazole (INN)
4-[2-[(1R,2R)-2-(2,5-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)pro
4-(2-((2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile

MDL Number

MFCD06407745

FAQ

What is Isavuconazole (CAS: 241479-67-4)?

Isavuconazole is an antifungal medication with the chemical formula C22H28N4O2. It belongs to the triazole class of antifungals and is known for its broad-spectrum activity against various fungi. It is used clinically to treat invasive fungal infections and is available in oral and intravenous formulations. Its molecular structure allows it to inhibit fungal cell membrane synthesis by targeting the enzyme lanosterol 14α-demethylase.

What are the main uses of Isavuconazole (CAS: 241479-67-4)?

Isavuconazole is primarily used to treat serious fungal infections such as aspergillosis, candidiasis, and other invasive mycoses. It is also applied in research for studying fungal biology and in pharmaceutical development as a therapeutic agent. Due to its broad antifungal activity and favorable pharmacokinetic properties, it is considered a valuable option in the treatment of systemic fungal infections.

Is Isavuconazole (CAS: 241479-67-4) safe?

Isavuconazole is generally considered safe when used as directed, but it may cause side effects such as nausea, headache, and liver enzyme elevation. It is important to follow safety guidelines and consult a healthcare professional before use. Proper handling and protective measures, including gloves and ventilation, should be taken during preparation and administration to minimize exposure risks.

How should Isavuconazole (CAS: 241479-67-4) be stored?

Isavuconazole should be stored in a cool, dry place away from moisture and light. It is typically kept at a temperature between 15°C and 30°C. The container should be tightly closed and protected from direct sunlight to maintain stability and potency. Always check the expiration date and store as per the manufacturer's instructions.