2-Bromo-3-chloro-5-nitropyridine

Basic Information

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CAS Number

22353-41-9

Molecular Formula

C5H2BrClN2O2

Molecular Weight

237.44 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Flash Point

130.7℃

SMILES

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C1=C(C=NC(=C1Cl)Br)[N+](=O)[O-]

InChI

InChI=1S/C5H2BrClN2O2/c6-5-4(7)1-3(2-8-5)9(10)11/h1-2H

InChIKey

VDVNBTTZUJOHJZ-UHFFFAOYSA-N

LogP

2.92890

Complexity

163

Synonyms & References

English

DS-10951
Pyridine, 2-bromo-3-chloro-5-nitro-
FT-0646031
AKOS015835790
CS-W021599
SCHEMBL10857430
A816141
J-508207
2-bromanyl-3-chloranyl-5-nitro-pyridine
SY006125
MFCD08061302
GEO-03650
2-Bromo-3-chloro-5-nitropyridine
22353-41-9
2-bromo-3-chloro-5-nitro-pyridine
AM62477
A929235
DTXSID50562007
2-Bromo-3-chloro-5-nitropyridine, AldrichCPR
2-bromo-3-chloro-5-nitro-Pyridine
Pyridine,2-bromo-3-chloro-5-nitro-
PubChem5773
KSC495O7B
AMPD00033
STL556629
BBL102821
TRA0067381
VP13636
RP28293
RP28288
BC003026

MDL Number

MFCD08061302

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9)?

2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9) is a yellow or orange crystalline solid with a molecular weight of 232.01 g/mol. It has a melting point of 214-215°C and is slightly soluble in water. This compound is known for its reactivity in nitro group reduction and bromination reactions. It is used in organic synthesis as a precursor to other nitrogen-containing compounds and is important in the development of pharmaceuticals and pesticides.

How is 2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9) typically synthesized?

2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9) is synthesized through the bromination of 3-chloro-5-nitropyridine using bromine in the presence of a Lewis acid catalyst such as aluminum trichloride. The reaction is conducted in an inert solvent like dichloromethane. The yield is around 85-90%, and the procedure is selective for the bromination of the 2-position. This method is widely used in the synthesis of functionalized pyridines for various applications.

What industries use 2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9)?

2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9) is primarily used in the pharmaceutical and pesticide industries. It serves as a key intermediate in the synthesis of several drug molecules. Additionally, this compound is employed in the development of sensors and semiconductors due to its unique electronic properties. Its use in organic synthesis also supports the growth of the chemical industry.

What precautions should be taken when handling 2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9)?

When handling 2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9), it is essential to follow strict safety protocols. Wearing personal protective equipment (PPE) such as gloves, goggles, and a lab coat is necessary. Work should be conducted in a well-ventilated area, preferably with a fume hood, to minimize exposure to vapors. In case of a spill, avoid direct contact and clean up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.