2-Bromo-3-chloro-5-nitropyridine(CAS: 22353-41-9)

2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9) is a yellow or orange crystalline solid with a molecular weight of 232.01 g/mol. It has a melting point of 214-215°C and is slightly soluble in water. This compound is known for its reactivity in nitro group reduction and bromination reactions. It is used in organic synthesis as a precursor to other nitrogen-containing compounds and is important in the development of pharmaceuticals and pesticides.

2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9) is synthesized through the bromination of 3-chloro-5-nitropyridine using bromine in the presence of a Lewis acid catalyst such as aluminum trichloride. The reaction is conducted in an inert solvent like dichloromethane. The yield is around 85-90%, and the procedure is selective for the bromination of the 2-position. This method is widely used in the synthesis of functionalized pyridines for various applications.

2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9) is primarily used in the pharmaceutical and pesticide industries. It serves as a key intermediate in the synthesis of several drug molecules. Additionally, this compound is employed in the development of sensors and semiconductors due to its unique electronic properties. Its use in organic synthesis also supports the growth of the chemical industry.

When handling 2-Bromo-3-chloro-5-nitropyridine (CAS: 22353-41-9), it is essential to follow strict safety protocols. Wearing personal protective equipment (PPE) such as gloves, goggles, and a lab coat is necessary. Work should be conducted in a well-ventilated area, preferably with a fume hood, to minimize exposure to vapors. In case of a spill, avoid direct contact and clean up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.