(2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-pentynoic acid | CAS No. 220497-98-3
(2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-pentynoic acid
Basic Information
CAS Number
220497-98-3
Molecular Formula
C20H17NO4
Molecular Weight
335.4 g/mol
AD
Basic Physical Properties
Melting Point
155 °C
Boiling Point
472°C (rough estimate)
Refractive Index
1.5600 (estimate)
Safety Information
View Safety InformationHazard Class
Class IRRITANT
Class IRRITANT
Synonyms & References
English
- CS-W008395
- (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-ynoic acid
- S-220497-98-3
- HY-W008395
- (R)-N-FMOC-PROPARYLGLYCINE
- SCHEMBL119859
- N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-(R)-2-AMINO-4-PENTYNOIC ACID
- AKOS025289366
- (R)-2-(Fmoc-amino)-4-pentynoic acid
- (R)-N-FMOC-PROPARGYLGLYCINE
- Fmoc-D-2-propargylglycine
- DTXSID60426505
- Fmoc-D-Gly(propargyl)-OH
- Fmoc-Propargyl-D-Gly-OH
- (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)pent-4-ynoic acid
- A878769
- DS-9750
- Fmoc-D-Pra-OH
- (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-ynoic acid
- N-alpha-(9-Fluorenylmethoxycarbonyl)-D-propargylglycine
- AC-9950
- Fmoc-D-proparglycine
- Fmoc-D-Propargylglycine
- (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pent-4-ynoic acid
- EN300-650058
- 220497-98-3
- J-014450
- LT0117
- N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-PROPARGYLGLYCINE
- (R)-2-(Fmoc-amino)-4-pentynoic acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)pent-4-ynoic acid
- Fmoc-D-propargylglycine (Fmoc-D-Pra-OH)
MDL Number
MFCD01311781
FAQ
What are the physical and chemical properties of (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-pentynoic acid (CAS: 220497-98-3)?
This compound is a white to off-white crystalline solid with a molecular weight of approximately 347.36 g/mol. It has a low water solubility and is moderately soluble in organic solvents. The compound is known for its reactivity, particularly in peptide coupling reactions and as a precursor in medicinal chemistry. It is stable under neutral conditions but can be sensitive to strong acid or base conditions.
How is (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-pentynoic acid (CAS: 220497-98-3) typically synthesized?
The compound is typically synthesized via a Fmoc (Fluorenylmethoxycarbonyl) protection strategy. The key steps include the coupling of 4-pentyne-2-carboxylic acid with 9-fluorenylmethyl chloroformate, followed by the introduction of the amino group using an amino alcohol. The yield is usually around 60-70%, and the reaction is catalyzed by standard coupling reagents.
What industries use (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-pentynoic acid (CAS: 220497-98-3)?
This compound is primarily used in the pharmaceutical industry as a key intermediate in the synthesis of various bioactive compounds. It is also utilized in the polymer industry for the development of novel materials with enhanced properties, and in the chemical sensor industry for the fabrication of highly sensitive detection devices.
What precautions should be taken when handling (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-pentynoic acid (CAS: 220497-98-3)?
When handling this compound, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and should be handled in a fume hood. In case of a spill, avoid inhalation and contact with skin. Refer to the Safety Data Sheet (SDS) for specific guidance on spill cleanup and disposal.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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