N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine

Basic Information

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CAS Number

200623-62-7

Molecular Formula

C39H34N2O5

Molecular Weight

610.71 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

232-237 °C

Specific Rotation

+10.4° - +16.4° (c=1, DMF)

SMILES

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C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)NC(=O)CCC(C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

InChI

InChI=1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m1/s1

InChIKey

WDGICUODAOGOMO-PGUFJCEWSA-N

LogP

6.866800000000006

Topological Polar Surface Area

104.73000000000002 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

946

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

C39H34N2O5
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)carbamoyl]butanoic acid
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N5-trityl-D-glutamine
J-300127
GS-6246
N~2~-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-N-(triphenylmethyl)-D-glutamine
HY-W010714
FD21533
AC-19294
AMY22639
SCHEMBL13227676
N2-Fmoc-N5-trityl-D-glutamine
MFCD00151924
DTXSID50647444
M03414
Fmoc-D-Gln(Trt)-OH
CS-W011430
N-Fmoc-N'-trityl-D-glutamine
KBP5W6GG2P
Fmoc-D-Gln(Trt)-OH, 97%
Q-101810
A814212
Nalpha-Fmoc-Ngamma-4-methyltrityl-D-asparagine
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-(tritylamino)pentanoic acid
200623-62-7
(R)-2-((((9H-FLUOREN-9-YL)METHOXY)CARBONYL)AMINO)-5-OXO-5-(TRITYLAMINO)PENTANOIC ACID
AKOS016842944
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-gamma-trityl-D-glutamine
N-(9-Fluorenylmethyloxycarbonyl)-N'-(triphenylmethyl)-D-glutamine
Fmoc-D-Gln(Trt)-OH N-α-Fmoc-N-δ-trityl-D-glutamine
AmbotzFAA1322

MDL Number

MFCD00151924

FAQ

What are the physical and chemical properties of N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine (CAS: 200623-62-7)?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine has a crystalline form with a molecular weight of approximately 894.5 g/mol. It has low water solubility, making it suitable for organic synthesis. The compound is reactive and can participate in esterification and amidation reactions. It is soluble in organic solvents like DMSO and acetonitrile.

How is N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine (CAS: 200623-62-7) typically synthesized?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine is synthesized via a multi-step process involving the coupling of trityl-D-glutamine with 9-(methoxycarbonyl)fluorene. The reaction typically requires a coupling reagent like HATU and a base like DIPEA. The yield is generally around 70-80% with good selectivity.

What industries use N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine (CAS: 200623-62-7)?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine is primarily used in pharmaceuticals and organic synthesis. It serves as a key intermediate in the synthesis of various bioactive compounds. Some applications include drug discovery, polymer synthesis, and as a building block for sensor development and semiconductor fabrication.

What precautions should be taken when handling N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine (CAS: 200623-62-7)?

Handling N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-D-glutamine requires PPE like gloves, goggles, and a lab coat. Work in a fume hood to avoid inhalation. Spills should be cleaned with solvents, and refer to the SDS for disposal.