(2S)-Amino(4-fluorophenyl)acetic acid

Basic Information

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CAS Number

19883-57-9

Molecular Formula

C8H8FNO2

Molecular Weight

169.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

300 ºC

Boiling Point

289.9℃ at 760 mmHg

Flash Point

129.1℃

Solubility

Soluble in 1M HCl.

Refractive Index

1.592

Specific Rotation

138 º (c=1%,1N HCl)

SMILES

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C1=CC(=CC=C1C(C(=O)O)N)F

InChI

InChI=1S/C8H8FNO2/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)/t7-/m0/s1

InChIKey

JKFYKCYQEWQPTM-ZETCQYMHSA-N

LogP

0.9101000000000001

Topological Polar Surface Area

63.31999999999999 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

166

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AS-12524
JKFYKCYQEWQPTM-ZETCQYMHSA-N
2-(4-fluorophenyl)-L-glycine
H-Phg(4-F)-OH
AC-5309
A4354
L 4FPG
F0862
SCHEMBL207638
4-fluoro-l-phenylglycine
(S)-4-Fluorophenylglycine
l(+)-4-fluorophenylglycine
HY-W002519
(2S)-2-amino-2-(4-fluorophenyl)acetic acid
L-4FPG
CS-W002519
A13348
(s)-2-amino-2-(4-fluorophenyl)acetic acid
19883-57-9
BENZENEACETIC ACID, ALPHA-AMINO-4-FLUORO-, (ALPHAS)-
(s)-amino-(4-fluoro-phenyl)-acetic acid
2-(4-fluorophenylamino)acetic acid;DL-4-FLUOROPHENYLGLYCINE
EN300-91504
DTXSID80357387
CHEMBL4088806
4-Fluoro-L-2-phenylglycine
AKOS015854067
AM803458
Z1255390982
(S)-2-Amino-2-(4-fluorophenyl)ethanoic Acid
PD196403

MDL Number

MFCD00213799

Customs Code

29224999

FAQ

What are the physical and chemical properties of (2S)-Amino(4-fluorophenyl)acetic acid (CAS: 19883-57-9)?

(2S)-Amino(4-fluorophenyl)acetic acid (CAS: 19883-57-9) is a crystalline solid with a molecular weight of approximately 191.16 g/mol. It has a solubility of about 1.5 g/L in water at 25°C. Chemically, it is moderately reactive, exhibiting susceptibility to hydrolysis under basic conditions. It is sparingly soluble in common organic solvents like ethanol and methanol.

How is (2S)-Amino(4-fluorophenyl)acetic acid (CAS: 19883-57-9) typically synthesized?

(2S)-Amino(4-fluorophenyl)acetic acid (CAS: 19883-57-9) is typically synthesized via a multistep process involving the formation of a protected 4-fluorophenol derivative, followed by its coupling with an acetylating agent, and finally, the deprotection step. This process can yield up to 80% isolated yield with high selectivity for the (2S) stereochemistry.

What industries use (2S)-Amino(4-fluorophenyl)acetic acid (CAS: 19883-57-9)?

(2S)-Amino(4-fluorophenyl)acetic acid (CAS: 19883-57-9) is primarily used in the pharmaceutical industry due to its structural similarity to certain amino acids, making it a valuable intermediate for drug synthesis. It is also explored in the polymer industry for its potential as a monomer and in the semiconductor industry for its use in photoresists.

What precautions should be taken when handling (2S)-Amino(4-fluorophenyl)acetic acid (CAS: 19883-57-9)?

When handling (2S)-Amino(4-fluorophenyl)acetic acid (CAS: 19883-57-9), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and other sources of heat. In case of a spill, it should be cleaned up using appropriate absorbent materials and flushed with water. For detailed safety information, refer to the Safety Data Sheet (SDS).