5-Fluoro-2,4-dimethoxyaniline

Basic Information

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CAS Number

195136-65-3

Molecular Formula

C8H10FNO2

Molecular Weight

171.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Physical State

Yellow to Brown Solid

SMILES

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COC1=CC(=C(C=C1N)F)OC

InChI

InChI=1S/C8H10FNO2/c1-11-7-4-8(12-2)6(10)3-5(7)9/h3-4H,10H2,1-2H3

InChIKey

QOIDQMOZTRAYET-UHFFFAOYSA-N

LogP

1.4251

Topological Polar Surface Area

44.480000000000004 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

145

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class CORROSIVE Class CORROSIVE

Synonyms & References

English

5-Fluoro-2,4-dimethoxyaniline
2,4-Dimethoxy-5-fluoroaniline
5-fluoro-2,4-dimethoxybenzenamine
1-Amino-2,4-dimethoxy-5-fluorobenzene
5-Fluoro-2,4-dimethoxy-phenylamine
AC1Q4926
AG-L-22441
CTK4E1697
SureCN6371301
5-Fluoro-2,4-dimethoxy-phenylamine;5-FLUORO-2,4-DIMETHOXYANILINE
CS-0172561
5-fluoro-2,4-dimethoxyaniline
AKOS005259370
SCHEMBL6371301
195136-65-3
4-AMINO-4-(4-FLUOROPHENYL)CYCLOHEXANOL
Benzenamine, 5-fluoro-2,4-dimethoxy-
EN300-89875
VHA13665
BBL101531
DB-332988
BP-13412
PS-8688
DTXSID00444288
QOIDQMOZTRAYET-UHFFFAOYSA-N
STL555327
A848676
MFCD12547861

MDL Number

MFCD12547861

FAQ

What are the physical and chemical properties of 5-Fluoro-2,4-dimethoxyaniline (CAS: 195136-65-3)?

5-Fluoro-2,4-dimethoxyaniline is a white crystalline solid with a molecular weight of approximately 215.14 g/mol. It is slightly soluble in water and has good solubility in organic solvents such as ethanol and acetone. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions.

How is 5-Fluoro-2,4-dimethoxyaniline (CAS: 195136-65-3) typically synthesized?

5-Fluoro-2,4-dimethoxyaniline can be synthesized through electrophilic aromatic substitution of 2,4-dimethoxyaniline with fluorine in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction typically provides good yield and high selectivity for the fluorination at the meta-position.

What industries use 5-Fluoro-2,4-dimethoxyaniline (CAS: 195136-65-3)?

5-Fluoro-2,4-dimethoxyaniline is primarily used in the pharmaceutical industry for the synthesis of drugs and intermediates. It also finds applications in the production of certain polymers and as a reagent in analytical chemistry and as a component in sensors and semiconductors.

What precautions should be taken when handling 5-Fluoro-2,4-dimethoxyaniline (CAS: 195136-65-3)?

When handling 5-Fluoro-2,4-dimethoxyaniline, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. It should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents and followed by thorough decontamination. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.