5-Fluoro-2,4-dimethoxyaniline(CAS: 195136-65-3)

5-Fluoro-2,4-dimethoxyaniline is a white crystalline solid with a molecular weight of approximately 215.14 g/mol. It is slightly soluble in water and has good solubility in organic solvents such as ethanol and acetone. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions.

5-Fluoro-2,4-dimethoxyaniline can be synthesized through electrophilic aromatic substitution of 2,4-dimethoxyaniline with fluorine in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction typically provides good yield and high selectivity for the fluorination at the meta-position.

5-Fluoro-2,4-dimethoxyaniline is primarily used in the pharmaceutical industry for the synthesis of drugs and intermediates. It also finds applications in the production of certain polymers and as a reagent in analytical chemistry and as a component in sensors and semiconductors.

When handling 5-Fluoro-2,4-dimethoxyaniline, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. It should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents and followed by thorough decontamination. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.