4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine

Basic Information

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CAS Number

190728-25-7

Molecular Formula

C17H16N2O3

Molecular Weight

296.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

No data available

Melting Point

214°C

Boiling Point

481.8±45.0 °C at 760 mmHg

Flash Point

245.2±28.7 °C

SMILES

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COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)N

InChI

InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3

InChIKey

VXEQRXJATQUJSN-UHFFFAOYSA-N

LogP

3.626500000000002

Topological Polar Surface Area

66.60000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

347

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

4-(6,7-dimethoxyquinolin-4-yl)oxyaniline
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
,4-[(6,7-diMethoxy-4-quinolinyl)oxy]-BenzenaMine
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline
ACETAMIDE,N-[5-[BIS(2-METHOXYETHYL)AMINO]-2-[2-(2-IODO-4,6-DINITROPHENYL)DIAZENYL]-4-METHOXYPHENYL]-
BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]-
4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline
4-(6,7-dimethoxyquinolin-4-yloxy)aniline
4-(6,7-DIMETHOXY-QUINOLIN-4-YLOXY)-P
4-(6,7-dimethoxyquinolin-4-yloxy)phenylamine
4-(6,7-dimethoxyquinoline-4-yloxy)phenylamine
4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline
6,7-Dimethoxy-4-(4-aminophenyloxy)quinoline
AGN-PC-00CAMZ
SureCN167396
4-(4-Aminophenoxy)-6,7-dimethoxyquinoline
[4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]amine
Intermediate 1 of Cabozantinib
4-(6,7-dimethoxy quinolinoxy) aniline
6,7-Dimethoxy-4-(4-aminophenyloxy)quinolone
4-(2,3-dimethoxynaphthalen-5-yloxy)benzenamine
BenzeMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]-
4-(6,7-DIMETHOXY-QUINOLIN-4-YLOXY)-PHENYLAMINE
VXEQRXJATQUJSN-UHFFFAOYSA-N
BDBM153646
BCP10283
4-[(6,7-diMethoxy-4-quinolinyl)oxy]-BenzenaMine
4-[(6,7-dimethoxyquinolin-4-yl)oxy]aniline
4-(6,7-Dimethoxyquinolin-4-yloxy)benzenamine
AS-19585
4-[(6,7Dimethoxy-4-quinolyl)oxy]aniline

MDL Number

MFCD19685633

FAQ

What are the physical and chemical properties of 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine (CAS: 190728-25-7)?

4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine is a crystalline compound with a molecular weight of approximately 332.27 g/mol. It is sparingly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong acids or bases. It shows good reactivity with nucleophiles and electrophiles.

How is 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine (CAS: 190728-25-7) typically synthesized?

4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine is typically synthesized through a multistep process involving the formation of 6,7-dimethoxyquinoline followed by its coupling with phenol in the presence of a suitable base. Commonly used catalysts include palladium complexes, and the reaction is typically carried out in anhydrous organic solvents at room temperature, yielding a purifiable product with good selectivity and high yield.

What industries use 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine (CAS: 190728-25-7)?

4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine finds application in the pharmaceutical industry for the development of certain drugs, and in the chemical industry for its use as an intermediate in the synthesis of other compounds. It is also utilized in the production of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine (CAS: 190728-25-7)?

When handling 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a fume hood, and spills should be handled with caution using appropriate spill kits. Immediate access to a safety data sheet (SDS) is essential for reference in case of emergencies. Handling should be done in a well-ventilated area to avoid inhalation of dust or vapor.