How is 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine (CAS: 190728-25-7) typically synthesized?

4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine is typically synthesized through a multistep process involving the formation of 6,7-dimethoxyquinoline followed by its coupling with phenol in the presence of a suitable base. Commonly used catalysts include palladium complexes, and the reaction is typically carried out in anhydrous organic solvents at room temperature, yielding a purifiable product with good selectivity and high yield.