4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine(CAS: 190728-25-7)

4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine is a crystalline compound with a molecular weight of approximately 332.27 g/mol. It is sparingly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong acids or bases. It shows good reactivity with nucleophiles and electrophiles.

4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine is typically synthesized through a multistep process involving the formation of 6,7-dimethoxyquinoline followed by its coupling with phenol in the presence of a suitable base. Commonly used catalysts include palladium complexes, and the reaction is typically carried out in anhydrous organic solvents at room temperature, yielding a purifiable product with good selectivity and high yield.

4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine finds application in the pharmaceutical industry for the development of certain drugs, and in the chemical industry for its use as an intermediate in the synthesis of other compounds. It is also utilized in the production of sensors and semiconductors due to its unique chemical properties.

When handling 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a fume hood, and spills should be handled with caution using appropriate spill kits. Immediate access to a safety data sheet (SDS) is essential for reference in case of emergencies. Handling should be done in a well-ventilated area to avoid inhalation of dust or vapor.