Ac-VDVAD-pNA | CAS No. 189684-53-5

Ac-VDVAD-pNA

Basic Information

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CAS Number

189684-53-5

Molecular Formula

C29H41N7O12

Molecular Weight

679.7 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Solubility

DMSO: 2 mM

SMILES

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CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C

InChI

InChI=1S/C29H41N7O12/c1-13(2)23(31-16(6)37)29(46)34-20(12-22(40)41)27(44)35-24(14(3)4)28(45)30-15(5)25(42)33-19(11-21(38)39)26(43)32-17-7-9-18(10-8-17)36(47)48/h7-10,13-15,19-20,23-24H,11-12H2,1-6H3,(H,30,45)(H,31,37)(H,32,43)(H,33,42)(H,34,46)(H,35,44)(H,38,39)(H,40,41)

InChIKey

SIOKOOKURWWOID-UHFFFAOYSA-N

LogP

1.80920

Complexity

1230

Synonyms & References

English

189684-53-5
N-Acetylvalyl-alpha-aspartylvalylalanyl-N-(4-nitrophenyl)-alpha-asparagine
3-[2-[[2-[[2-[(2-acetamido-3-methylbutanoyl)amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-(4-nitroanilino)-4-oxobutanoic acid
DTXSID00657593
L-a-Asparagine, N-acetyl-L-valyl-L-a-aspartyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-
AC-VAL-ASP-VAL-ALA-ASP-PNA
Ac-VDVAD-pNA
Ac-Val-Asp-Gln-Gln-Asp-paranitroanilide
Ac-Val-Asp-Gln-Gln-Asp-PNA
Ac-Val-Asp-Val-Ala-Asp-paranitroanilide
AC-VAL-ASP-VAL-ALA-ASP-PNA: AC-VDVAD-PNA
Ac-VDQQD-PNA
PNA142
PNA161
CASPASE-2 SUBSTRATE IV
CASPASE 2 SUBSTRATE, CHROMOGENIC
CASPASE-2 SUBSTRATE IV, COLORIMETRIC
CASPASE 2 (ICH-1) SUBSTRATE 1, CHROMOGENIC

MDL Number

MFCD01862575

FAQ

What regulatory guidelines apply to Ac-VDVAD-pNA (CAS: 189688-53-5)?

Ac-VDVAD-pNA (CAS: 189688-53-5) falls under the regulatory guidelines of the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), which includes classification for health hazards, environmental hazards, and flammability. In the European Union, it is subject to the REACH regulations for the registration, evaluation, authorization, and restriction of chemical substances. Additionally, the U.S. FDA and EPA have specific requirements for the handling, transport, and disposal of such compounds, particularly regarding their potential biological effects and environmental impact.

Are there alternatives to Ac-VDVAD-pNA (CAS: 189688-53-5) in synthesis?

For synthesizing similar functions, alternatives to Ac-VDVAD-pNA (CAS: 189688-53-5) include other fluorometric substrates like Ac-DEVD-pNA and Ac-LEHD-pNA, which are commonly used for caspase activity assays. These alternatives offer similar enzymatic cleavage properties but may have different specificities and substrate affinities. Researchers often choose based on the specific caspase isoform they are studying and the experimental requirements.

What is the market or research trend for Ac-VDVAD-pNA (CAS: 189688-53-5)?

The market for Ac-VDVAD-pNA (CAS: 189688-53-5) is growing due to its increasing use in biochemical and cellular assays for caspase activity. Research trends indicate a rising interest in understanding apoptosis pathways, which Ac-VDVAD-pNA is a key reagent for. The compound is also gaining popularity in cancer research and drug discovery, where it helps in identifying and validating caspase inhibitors. Demand is expected to continue increasing with advancements in these fields.

How should waste containing Ac-VDVAD-pNA (CAS: 189688-53-5) be handled?

Waste containing Ac-VDVAD-pNA (CAS: 189688-53-5) should be managed according to the relevant regulations of GHS, REACH, FDA, and EPA. Proper collection should occur in designated waste containers, ensuring that the waste is labeled appropriately. Safe disposal methods include incineration or professional chemical waste disposal services. Precautions should be taken to prevent environmental contamination, and all handling should comply with local and international environmental protection standards to ensure safety and sustainability.