Fmoc-thr(tbu)-ol

Basic Information

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CAS Number

189337-28-8

Molecular Formula

C23H29NO4

Molecular Weight

383.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

53-57°C

Boiling Point

576.497℃/760mmHg

Flash Point

302.454℃

Refractive Index

1.563

Specific Rotation

+11° (c = 1, MeOH)

SMILES

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CC(C(CO)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)OC(C)(C)C

InChI

InChI=1S/C23H29NO4/c1-15(28-23(2,3)4)21(13-25)24-22(26)27-14-20-18-11-7-5-9-16(18)17-10-6-8-12-19(17)20/h5-12,15,20-21,25H,13-14H2,1-4H3,(H,24,26)/t15-,21-/m1/s1

InChIKey

LBVPBNDGSCZOTB-QVKFZJNVSA-N

LogP

4.0896000000000035

Topological Polar Surface Area

67.79 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

495

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

M03453
Carbamic acid, N-[(1R,2R)-2-(1,1-dimethylethoxy)-1-(hydroxymethyl)propyl]-, 9H-fluoren-9-ylmethyl ester
AKOS015840319
FMOC-O-TERT-BUTYL-L-THREONINOL
DTXSID60456786
A880457
189337-28-8
fmoc-(2r,3r)-2-amino-3-t-butoxy-1-butanol
(9H-fluoren-9-yl)methyl (2R,3R)-3-tert-butoxy-1-hydroxybutan-2-ylcarbamate
(9H-Fluoren-9-yl)methyl [(2R,3R)-3-tert-butoxy-1-hydroxybutan-2-yl]carbamate
Fmoc-L-Threoninol(tBu)
Carbamic acid,[(1R,2R)-2-(1,1-dimethylethoxy)-1-(hydroxymethyl)propyl]-,9H-fluoren-9-ylmethyl ester(9ci)
AS-19185
AKOS015892818
MFCD00235950
Fmoc-Threoninol(OtBu)
9H-fluoren-9-ylmethyl N-[(2R,3R)-1-hydroxy-3-[(2-methylpropan-2-yl)oxy]butan-2-yl]carbamate
(9H-Fluoren-9-yl)methyl ((2R,3R)-3-(tert-butoxy)-1-hydroxybutan-2-yl)carbamate
CS-W011755
(2R,3R)-2-(Fmoc-amino)-3-tert-butoxy-1-butanol
AC-4560
FMOC-THR(TBU)-OL
Fmoc-(2R,3R)-2-Amino-3-T-Butoxy-1-Butanol
Carbamic acid,[(1R,2R)-2-(1,1-dimethylethoxy)-1-(hydroxymethyl)propyl]-,9H-fluoren-9-ylmethyl ...
Carbamic acid,[(1R,2R)-2-(1,1-dimethylethoxy)-1-(hydroxymethyl)propyl]-,9H-fluoren-9-ylmethyl ester (9CI)
Fmoc-L-Thr(tBu)-Ol
FMOC-O-T-BUTYL-L-THREONINOL
Fmoc-Thr(tBu)-OL
Fmoc-Threoninol(tBu)
AmbotzFAL1034
Fmoc-Thr(t-Bu)-ol

MDL Number

MFCD00235950

FAQ

What are the physical and chemical properties of Fmoc-thr(tbu)-ol (CAS: 189337-28-8)?

Fmoc-thr(tbu)-ol (CAS: 189337-28-8) is a white crystalline powder with a molecular weight of approximately 327.41 g/mol. It is sparingly soluble in common organic solvents like dichloromethane and acetonitrile. It is not very reactive under normal conditions but can participate in esterification reactions. This compound shows good solubility in water and can be used as a solid or dissolved in solvents for various applications.

How is Fmoc-thr(tbu)-ol (CAS: 189337-28-8) typically synthesized?

Fmoc-thr(tbu)-ol is typically synthesized by the saponification of Fmoc-Thr(tert-butyloxycarbonyl)-butyrate. The reaction involves the hydrolysis of the ester bond under basic conditions, which releases tert-butanol and forms the corresponding alcohol. This method ensures high yield and good selectivity, making it suitable for large-scale production.

What industries use Fmoc-thr(tbu)-ol (CAS: 189337-28-8)?

Fmoc-thr(tbu)-ol (CAS: 189337-28-8) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of peptide-based drugs and other biologically active compounds. Additionally, it has applications in the preparation of polymers and sensors due to its functional groups and reactivity.

What precautions should be taken when handling Fmoc-thr(tbu)-ol (CAS: 189337-28-8)?

When handling Fmoc-thr(tbu)-ol (CAS: 189337-28-8), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents, and the area should be thoroughly washed down. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency protocols.