Fmoc-thr(tbu)-ol(CAS: 189337-28-8)

Fmoc-thr(tbu)-ol (CAS: 189337-28-8) is a white crystalline powder with a molecular weight of approximately 327.41 g/mol. It is sparingly soluble in common organic solvents like dichloromethane and acetonitrile. It is not very reactive under normal conditions but can participate in esterification reactions. This compound shows good solubility in water and can be used as a solid or dissolved in solvents for various applications.

Fmoc-thr(tbu)-ol is typically synthesized by the saponification of Fmoc-Thr(tert-butyloxycarbonyl)-butyrate. The reaction involves the hydrolysis of the ester bond under basic conditions, which releases tert-butanol and forms the corresponding alcohol. This method ensures high yield and good selectivity, making it suitable for large-scale production.

Fmoc-thr(tbu)-ol (CAS: 189337-28-8) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of peptide-based drugs and other biologically active compounds. Additionally, it has applications in the preparation of polymers and sensors due to its functional groups and reactivity.

When handling Fmoc-thr(tbu)-ol (CAS: 189337-28-8), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents, and the area should be thoroughly washed down. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency protocols.