Natalizumab | CAS No. 189261-10-7

Natalizumab

Basic Information

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CAS Number

189261-10-7

Molecular Formula

C46H80N14O16SSe

Molecular Weight

1196.26 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

SMILES

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CC[C@H](C)[C@@H](C(=N[C@@H](CC(C)C)C(=N[C@@H](C)C(=N[C@@H]([C@@H](C)O)C(=N[C@@H](C)C(=N[C@@H](CC(=N)O)C=O)O)O)O)O)O)NN[C@@H](CCC(=N)O)C(=N[C@@H](C[SeH])C(=O)C(=O)[C@H](CCSC)N=C([C@H](C)NN[C@@H](CC(=N)O)C(=O)O)O)O

InChI

InChI=1S/C46H80N14O16SSe/c1-10-21(4)35(44(73)54-29(15-20(2)3)43(72)50-23(6)40(69)56-36(25(8)62)45(74)51-22(5)39(68)52-26(18-61)16-33(48)64)60-58-28(11-12-32(47)63)42(71)55-31(19-78)38(67)37(66)27(13-14-77-9)53-41(70)24(7)57-59-30(46(75)76)17-34(49)65/h18,20-31,35-36,57-60,62,78H,10-17,19H2,1-9H3,(H2,47,63)(H2,48,64)(H2,49,65)(H,50,72)(H,51,74)(H,52,68)(H,53,70)(H,54,73)(H,55,71)(H,56,69)(H,75,76)/t21-,22-,23-,24-,25+,26-,27-,28-,29-,30-,31-,35-,36-/m0/s1

InChIKey

UVWKUTFXSMNLGZ-IOVPNUEZSA-N

LogP

2.1177100000000015

Topological Polar Surface Area

517.23 Å²

Hydrogen Bond Donor/Acceptor

19 / 30

Synonyms & References

English

Natalizumab
Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer
Natalizumab-Tysabri

FAQ

What is Natalizumab (CAS: 189261-10-7)?

Natalizumab (CAS: 189261-10-7) is a humanized monoclonal antibody used to treat multiple sclerosis and Crohn's disease. It targets the integrin receptor alpha 4, which is involved in the migration of immune cells across the blood-brain barrier and intestinal lining.

What are the main uses of Natalizumab (CAS: 189261-10-7)?

Natalizumab (CAS: 189261-10-7) is primarily used to treat relapsing forms of multiple sclerosis and active inflammatory Crohn's disease. It helps in reducing the frequency of relapses and maintaining remission in MS patients and improving symptoms and remission in Crohn's disease patients.

Is Natalizumab (CAS: 189261-10-7) safe?

Natalizumab (CAS: 189261-10-7) is generally considered safe when used under medical supervision. However, it carries a risk of progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection. Patients must undergo regular monitoring for early signs of PML and other potential adverse effects.

How should Natalizumab (CAS: 189261-10-7) be stored?

Natalizumab (CAS: 189261-10-7) should be stored at 2-8°C (36-46°F) in its original vial. It should be kept away from direct light and protected from extreme temperatures. Do not freeze the product, and discard any unused portion that has been thawed or exposed to temperatures above 25°C (77°F).