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Natalizumab(CAS: 189261-10-7)
CAS Number
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Basic Information
Molecular Formula
C46H80N14O16SSe
Molecular Weight
1196.26 g/mol
Chemical Identifiers
SMILES
CC[C@H](C)[C@@H](C(=N[C@@H](CC(C)C)C(=N[C@@H](C)C(=N[C@@H]([C@@H](C)O)C(=N[C@@H](C)C(=N[C@@H](CC(=N)O)C=O)O)O)O)O)O)NN[C@@H](CCC(=N)O)C(=N[C@@H](C[SeH])C(=O)C(=O)[C@H](CCSC)N=C([C@H](C)NN[C@@H](CC(=N)O)C(=O)O)O)O
InChIKey
UVWKUTFXSMNLGZ-IOVPNUEZSA-N
Database References
FAQ
Natalizumab (CAS: 189261-10-7) is a humanized monoclonal antibody used to treat multiple sclerosis and Crohn's disease. It targets the integrin receptor alpha 4, which is involved in the migration of immune cells across the blood-brain barrier and intestinal lining.
Natalizumab (CAS: 189261-10-7) is primarily used to treat relapsing forms of multiple sclerosis and active inflammatory Crohn's disease. It helps in reducing the frequency of relapses and maintaining remission in MS patients and improving symptoms and remission in Crohn's disease patients.
Natalizumab (CAS: 189261-10-7) is generally considered safe when used under medical supervision. However, it carries a risk of progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection. Patients must undergo regular monitoring for early signs of PML and other potential adverse effects.
Natalizumab (CAS: 189261-10-7) should be stored at 2-8°C (36-46°F) in its original vial. It should be kept away from direct light and protected from extreme temperatures. Do not freeze the product, and discard any unused portion that has been thawed or exposed to temperatures above 25°C (77°F).
Safety Notice
Please verify product specifications and safety data before use. Contact the supplier for detailed safety information.
Always follow proper handling procedures
Contact Information
Contact Person
Fang Rui
wangkang@jskchem.com
Mobile
15221441005
Telephone
15221441005
Visit Website
https://www.jskchem.comAddress
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