N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide | CAS No. 1890208-58-8

N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide

Basic Information

CAS Number

1890208-58-8

Molecular Formula

C22H23N3O5S

Molecular Weight

441.51 g/mol

AD

Basic Physical Properties

COc1ccccc1N(S(=O)(=O)c1ccc(cc1)C)CC(=O)Nc1cnccc1OC

InChI

InChI=1S/C22H23N3O5S/c1-16-8-10-17(11-9-16)31(27,28)25(19-6-4-5-7-21(19)30-3)15-22(26)24-18-14-23-13-12-20(18)29-2/h4-14H,15H2,1-3H3,(H,24,26)

InChIKey

NAXWKPFXCOBXLE-UHFFFAOYSA-N

LogP

3.241220000000001

Topological Polar Surface Area

97.83 Ų

Hydrogen Bond Donor/Acceptor

1 / 8

Synonyms & References

English

  • Compound 7P

FAQ

What are the physical and chemical properties of N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide (CAS: 1890208-58-8)?

N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide is a crystalline compound with a molecular weight of approximately 531.45 g/mol. It has a melting point of around 150-155°C and is poorly soluble in water but soluble in common organic solvents such as DMSO and DMF. Chemically, it is relatively stable but can undergo hydrolysis under acidic or basic conditions. It is used in applications requiring specific reactivity and stability.

How is N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide (CAS: 1890208-58-8) typically synthesized?

N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide is synthesized through multistep reactions involving condensation and sulfonation steps. Commonly, it involves the reaction of an appropriate 2-methoxyphenyl derivative with 4-methoxy-3-pyridinylglycine in the presence of a base and a sulfonyl chloride, followed by purification through recrystallization or column chromatography. Yields are typically moderate to good.

What industries use N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide (CAS: 1890208-58-8)?

N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide is primarily used in pharmaceuticals and fine chemicals for its specific reactivity and stability. It is also utilized in the development of new materials for sensors and semiconductors where precise molecular properties are required.

What precautions should be taken when handling N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide (CAS: 1890208-58-8)?

When handling N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbents. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.

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