How is N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide (CAS: 1890208-58-8) typically synthesized?

N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide is synthesized through multistep reactions involving condensation and sulfonation steps. Commonly, it involves the reaction of an appropriate 2-methoxyphenyl derivative with 4-methoxy-3-pyridinylglycine in the presence of a base and a sulfonyl chloride, followed by purification through recrystallization or column chromatography. Yields are typically moderate to good.