N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide(CAS: 1890208-58-8)

N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide is a crystalline compound with a molecular weight of approximately 531.45 g/mol. It has a melting point of around 150-155°C and is poorly soluble in water but soluble in common organic solvents such as DMSO and DMF. Chemically, it is relatively stable but can undergo hydrolysis under acidic or basic conditions. It is used in applications requiring specific reactivity and stability.

N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide is synthesized through multistep reactions involving condensation and sulfonation steps. Commonly, it involves the reaction of an appropriate 2-methoxyphenyl derivative with 4-methoxy-3-pyridinylglycine in the presence of a base and a sulfonyl chloride, followed by purification through recrystallization or column chromatography. Yields are typically moderate to good.

N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide is primarily used in pharmaceuticals and fine chemicals for its specific reactivity and stability. It is also utilized in the development of new materials for sensors and semiconductors where precise molecular properties are required.

When handling N~2~-(2-Methoxyphenyl)-N-(4-methoxy-3-pyridinyl)-N~2~-[(4-methylphenyl)sulfonyl]glycinamide, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbents. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.