N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide | CAS No. 1848242-58-9
N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide
Basic Information
CAS Number
1848242-58-9
Molecular Formula
C20H13ClF2N4O4S
Molecular Weight
478.86 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- PI3K/mTOR Inhibitor-2
FAQ
What are the physical and chemical properties of N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide (CAS: 1848242-58-9)?
N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide (CAS: 1848242-58-9) is a crystalline compound with a molecular weight of approximately 501.26 g/mol. It is slightly soluble in water and highly soluble in organic solvents like dimethylformamide (DMF). The compound exhibits good stability under normal conditions but can be reactive towards acid and bases. It is typically used in pharmaceutical applications where its chemical properties make it suitable for specific drug formulations.
How is N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide (CAS: 1848242-58-9) typically synthesized?
N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide (CAS: 1848242-58-9) is synthesized through a multi-step process involving the condensation of 2,4-difluorobenzenesulfonamide with 5-(3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinylamine. The synthesis typically requires the use of a base like sodium hydride and is optimized for high yield and selectivity. Proper handling of reagents and monitoring of reaction progress are crucial for successful synthesis.
What industries use N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide (CAS: 1848242-58-9)?
N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide (CAS: 1848242-58-9) is primarily used in the pharmaceutical industry. It serves as a precursor for the development of novel drugs with specific biological activities. Additionally, it may find applications in research and development for other industries such as polymers and sensors, where its unique chemical properties can be exploited.
What precautions should be taken when handling N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide (CAS: 1848242-58-9)?
When handling N-[5-(3-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide (CAS: 1848242-58-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handling should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be promptly cleaned up using appropriate absorbents, and the area should be properly ventilated. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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