4-Amino-3-fluorophenol hydrochloride (1:1)

Basic Information

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CAS Number

18266-53-0

Molecular Formula

C6H7ClFNO

Molecular Weight

163.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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C1=CC(=C(C=C1O)F)N.Cl

InChI

InChI=1S/C6H6FNO.ClH/c7-5-3-4(9)1-2-6(5)8;/h1-3,9H,8H2;1H

InChIKey

BUNOVSISSBLYTC-UHFFFAOYSA-N

LogP

1.5352999999999999

Topological Polar Surface Area

46.25 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

99.1

Synonyms & References

English

AKOS015910012
4-AMINO-3-FLUOROPHENOL HCL
18266-53-0
DTXSID90661200
BCP19739
A880874
4-Amino-3-fluorophenol--hydrogen chloride (1/1)
2-Fluoro-4-hydroxyaniline, HCl
4-amino-3-fluorophenol;hydrochloride
2-Fluoro-4-hydroxyaniline hydrochloride
4-Amino-3-fluorophenolhydrochloride
BUNOVSISSBLYTC-UHFFFAOYSA-N
SCHEMBL2291784
MFCD01632189
4-Amino-3-fluorophenol hydrochloride
Phenol, 4-amino-3-fluoro-, hydrochloride (1:1)
AMY19947
4-Amino-3-fluorophenol,hydrochloride
2-Fluoro-4-hydroxyaniline HCl
DS-6599
CS-M2394
AB09438
Phenol,4-amino-3-fluoro-, hydrochloride (1:1)
2-Fluoro-4-Hydroxyaniline Hydrochloride
AK122288
C6H6FNO.ClH
4-amino-3-fluorophenol, chloride
SBB087739
PC6096
AX8074860
V3930

MDL Number

MFCD01632189

Customs Code

2922299090

FAQ

What are the physical and chemical properties of 4-Amino-3-fluorophenol hydrochloride (CAS: 18266-53-0)?

4-Amino-3-fluorophenol hydrochloride (CAS: 18266-53-0) is a crystalline solid with a molecular weight of approximately 214.65 g/mol. It is slightly soluble in water and ethanol. This compound is known to be reactive towards bases and reducing agents. It is often used as an intermediate in pharmaceutical and chemical synthesis due to its chemical reactivity and functionality.

How is 4-Amino-3-fluorophenol hydrochloride (CAS: 18266-53-0) typically synthesized?

4-Amino-3-fluorophenol hydrochloride (CAS: 18266-53-0) can be synthesized through a two-step process. First, 3-fluoroaniline is treated with hydrochloric acid to form the hydrochloride salt. Then, the 4-amino group is introduced by amination using an appropriate amine under basic conditions. This process typically yields a product with good selectivity and high purity.

What industries use 4-Amino-3-fluorophenol hydrochloride (CAS: 18266-53-0)?

4-Amino-3-fluorophenol hydrochloride (CAS: 18266-53-0) is primarily used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also has applications in the polymer industry for its reactive functionalities, and in the sensor industry due to its reactivity and ease of functionalization. Additionally, it can be used in semiconductor applications for certain organic electronic devices.

What precautions should be taken when handling 4-Amino-3-fluorophenol hydrochloride (CAS: 18266-53-0)?

When handling 4-Amino-3-fluorophenol hydrochloride (CAS: 18266-53-0), appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation. Spills should be contained and cleaned up using appropriate absorbents, and the area should be adequately rinsed. The material safety data sheet (MSDS) should always be referenced for detailed safety information.