2-Bromo-4'-chloro-1,1'-biphenyl

Basic Information

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CAS Number

179526-95-5

Molecular Formula

C12H8BrCl

Molecular Weight

267.55 g/mol

Basic Physical Properties

Melting Point

39.0 to 43.0 deg-C

Boiling Point

325.5℃ at 760 mmHg

SMILES

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C1=CC=C(C(=C1)C2=CC=C(C=C2)Cl)Br

InChI

InChI=1S/C12H8BrCl/c13-12-4-2-1-3-11(12)9-5-7-10(14)8-6-9/h1-8H

InChIKey

WSHZWUXRWQVZQP-UHFFFAOYSA-N

LogP

4.769500000000002

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

175

Synonyms & References

English

2-Bromo-4'-chloro-1,1'-biphenyl
2'-Bromo-4-chlorobiphenyl
1-bromo-2-(4-chlorophenyl)benzene
2'-BROMO-4-CHLORO-BIPHENYL
2-Bromo-4'-chlorobiphenyl
2-Bromo-4`-chloro-bipheny
2-Bromo-4'-chloro-1'-biphenyl
1,1'-Biphenyl, 2-bromo-4'-chloro-
2'-Bromo-4-chloro-biphenyl
A850148
AMY17901
SCHEMBL554192
2-BROMO-4'-CHLOROBIPHENYL
DTXSID30513491
MFCD18072809
2-Bromo-4'-chloro-biphenyl
WSHZWUXRWQVZQP-UHFFFAOYSA-N
179526-95-5
CS-0135849
SY039768
W-206269
DB-338043
2'-bromo-4-chlorobiphenyl
SB67001
FS-4947
2-Bromo-4 inverted exclamation mark -chlorobiphenyl
B5253
AKOS016011128

MDL Number

MFCD18072809

FAQ

What are the physical and chemical properties of 2-Bromo-4'-chloro-1,1'-biphenyl (CAS: 179526-95-5)?

2-Bromo-4'-chloro-1,1'-biphenyl is a crystalline solid with a molecular weight of approximately 256.03 g/mol. It is slightly soluble in common organic solvents such as chloroform and dichloromethane. Reactivity is moderate, typically requiring heating or the presence of a catalyst for transformations. It is less reactive towards nucleophiles compared to bromine substituents but can undergo substitution reactions under specific conditions.

How is 2-Bromo-4'-chloro-1,1'-biphenyl (CAS: 179526-95-5) typically synthesized?

2-Bromo-4'-chloro-1,1'-biphenyl is commonly synthesized via bromination of 4'-chlorophenylphenyl ether using N-bromosuccinimide (NBS) in the presence of a radical initiator. The reaction yields a mixture that requires purification by recrystallization. Other methods include direct coupling reactions under photoreduction or palladium-catalyzed cross-coupling conditions.

What industries use 2-Bromo-4'-chloro-1,1'-biphenyl (CAS: 179526-95-5)?

2-Bromo-4'-chloro-1,1'-biphenyl is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a monomer or modifier. Additionally, it is utilized in the development of sensors and as a material in semiconductor technologies due to its unique electronic properties.

What precautions should be taken when handling 2-Bromo-4'-chloro-1,1'-biphenyl (CAS: 179526-95-5)?

When handling 2-Bromo-4'-chloro-1,1'-biphenyl, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation and skin contact risks. In case of a spill, use appropriate cleanup materials and consult the safety data sheet (SDS) for specific guidelines. Avoid contact with water and ensure proper disposal according to hazardous waste regulations.