2-Bromo-4'-chloro-1,1'-biphenyl(CAS: 179526-95-5)

2-Bromo-4'-chloro-1,1'-biphenyl is a crystalline solid with a molecular weight of approximately 256.03 g/mol. It is slightly soluble in common organic solvents such as chloroform and dichloromethane. Reactivity is moderate, typically requiring heating or the presence of a catalyst for transformations. It is less reactive towards nucleophiles compared to bromine substituents but can undergo substitution reactions under specific conditions.

2-Bromo-4'-chloro-1,1'-biphenyl is commonly synthesized via bromination of 4'-chlorophenylphenyl ether using N-bromosuccinimide (NBS) in the presence of a radical initiator. The reaction yields a mixture that requires purification by recrystallization. Other methods include direct coupling reactions under photoreduction or palladium-catalyzed cross-coupling conditions.

2-Bromo-4'-chloro-1,1'-biphenyl is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a monomer or modifier. Additionally, it is utilized in the development of sensors and as a material in semiconductor technologies due to its unique electronic properties.

When handling 2-Bromo-4'-chloro-1,1'-biphenyl, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation and skin contact risks. In case of a spill, use appropriate cleanup materials and consult the safety data sheet (SDS) for specific guidelines. Avoid contact with water and ensure proper disposal according to hazardous waste regulations.