1-Bromo-2-(difluoromethoxy)benzene

Basic Information

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CAS Number

175278-33-8

Molecular Formula

C7H5BrF2O

Molecular Weight

223.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

199 ºC

Flash Point

88 ºC

SMILES

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C1=CC=C(C(=C1)OC(F)F)Br

InChI

InChI=1S/C7H5BrF2O/c8-5-3-1-2-4-6(5)11-7(9)10/h1-4,7H

InChIKey

VHEICCMNYWNFQX-UHFFFAOYSA-N

LogP

3.0505000000000004

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

121

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SY024312
Benzene, 1-bromo-2-(difluoromethoxy)-
2-bromo-1-(difluoromethoxy)benzene
1-Bromo-2-(difluoromethoxy)benzene
SCHEMBL264299
175278-33-8
2-(Difluoromethoxy)Bromobenzene
1-bromo-2-difluoromethoxybenzene
CK2365
EN300-50138
CS-W007867
DTXSID00371762
TQU0264
1-bromo-2-difluoromethoxy-benzene
PS-7807
MFCD00221468
AKOS000172545
A812055
FT-0608783
Z295440616
2-(Difluoromethoxy)bromobenzene, AldrichCPR
AM61368
2-(Difluoromethoxy)bromobenzene
2-Bromo-1-(difluoromethoxy)benzene
Dibromoethoxychlorophosphonazo difluoromethoxybenzene
2-Bromo-alpha,alpha-difluoroanisole, 2-Bromophenyl difluoromethyl ether, 1-Bromo-2-(difluoromethoxy)benzene
2-(Difluoromethoxy)bromobenzene97%
2-(Difluoromethoxy)bromobenzene 97%
1-BROMO-2-(DIFLUOROMETHOXY)BENZENE, 97+%
2-Bromophenyl difluoromethyl ether
2-Bromo-alpha,alpha-difluoroanisole

MDL Number

MFCD00221468

Customs Code

2909309090

FAQ

What are the physical and chemical properties of 1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8)?

1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8) is a colorless crystalline solid with a molecular weight of approximately 226.03 g/mol. It has low water solubility, making it suitable for organic syntheses. It is moderately reactive, particularly towards nucleophiles, and is used in various synthetic transformations. It is soluble in common organic solvents like dichloromethane and ethyl acetate. Common applications include its use as an intermediate in organic synthesis and pharmaceuticals.

How is 1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8) typically synthesized?

1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8) is typically synthesized via bromination of 2-(difluoromethoxy)benzene using bromine in the presence of a Lewis acid catalyst, such as aluminum bromide. The reaction is carried out in an inert solvent, usually dichloromethane. The yield is good, and the product can be isolated by recrystallization. This method provides a selective and efficient route to the compound.

What industries use 1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8)?

1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8) is primarily used in the pharmaceutical and organic synthesis industries. It serves as an intermediate in the synthesis of various drugs and organic compounds. Additionally, it finds use in the polymer industry for developing new materials with specific properties. Its ability to enhance chemical reactivity makes it valuable in advanced sensor and semiconductor applications.

What precautions should be taken when handling 1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8)?

When handling 1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8), use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to prevent inhalation of vapors. Store the compound in a cool, dry place, away from direct sunlight and sources of heat. Dispose of any waste according to local regulations. Refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.