1-Bromo-2-(difluoromethoxy)benzene(CAS: 175278-33-8)

1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8) is a colorless crystalline solid with a molecular weight of approximately 226.03 g/mol. It has low water solubility, making it suitable for organic syntheses. It is moderately reactive, particularly towards nucleophiles, and is used in various synthetic transformations. It is soluble in common organic solvents like dichloromethane and ethyl acetate. Common applications include its use as an intermediate in organic synthesis and pharmaceuticals.

1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8) is typically synthesized via bromination of 2-(difluoromethoxy)benzene using bromine in the presence of a Lewis acid catalyst, such as aluminum bromide. The reaction is carried out in an inert solvent, usually dichloromethane. The yield is good, and the product can be isolated by recrystallization. This method provides a selective and efficient route to the compound.

1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8) is primarily used in the pharmaceutical and organic synthesis industries. It serves as an intermediate in the synthesis of various drugs and organic compounds. Additionally, it finds use in the polymer industry for developing new materials with specific properties. Its ability to enhance chemical reactivity makes it valuable in advanced sensor and semiconductor applications.

When handling 1-Bromo-2-(difluoromethoxy)benzene (CAS: 175278-33-8), use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to prevent inhalation of vapors. Store the compound in a cool, dry place, away from direct sunlight and sources of heat. Dispose of any waste according to local regulations. Refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.