2'-Deoxy-N-[(dimethylamino)methylene]guanosine

Basic Information

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CAS Number

17331-13-4

Molecular Formula

C13H18N6O4

Molecular Weight

322.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3CC(C(O3)CO)O

InChI

InChI=1S/C13H18N6O4/c1-18(2)5-15-13-16-11-10(12(22)17-13)14-6-19(11)9-3-7(21)8(4-20)23-9/h5-9,20-21H,3-4H2,1-2H3,(H,16,17,22)/b15-5+/t7-,8+,9+/m0/s1

InChIKey

ZXECVVVXPHBGGX-NMSRVTMWSA-N

LogP

-1.0182999999999989

Topological Polar Surface Area

128.85999999999999 Å²

Hydrogen Bond Donor/Acceptor

3 / 10

Complexity

525

Synonyms & References

English

2'-Deoxy-N-[(dimethylamino)methylidene]guanosine
DTXSID10654674
17331-13-4
2'-Deoxy-N2-Dimethylaminomethylene-Guanosine
AC-32166
DMF-dG
D94553
N'-[9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide
2-N-(N,N-dimethylaminomethylene)-2'-deoxyguanosine
2/'-DEOXY-N2-DIMETHYLAMINOMETHYLENE-GUANOSINE
Guanosine,2'-deoxy-N-[(dimethylamino)methylene]-
2'-DEOXY-N2-DMF-GUANOSINE
N'-[9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-3H-purin-2-yl]-N,N-dimethylmethanimidamide
2'-Deoxy-N2-Dimethylaminomethylen-Guanosine
N2-dimethylaminomethylene-2'-deoxyguanosine
2''-DEOXY-N2-DIMETHYLAMINOMETHYLEN-GUANOSINE
AX8294824

MDL Number

MFCD08704073

FAQ

What are the physical and chemical properties of 2'-Deoxy-N-[(dimethylamino)methylene]guanosine (CAS: 17331-13-4)?

2'-Deoxy-N-[(dimethylamino)methylene]guanosine is a solid compound with a molecular weight of approximately 371.22 g/mol. It has poor water solubility and good solubility in organic solvents like DMSO. This compound is known for its chemical stability under neutral and slightly acidic conditions but can react with strong acids or bases. It is used in the synthesis of nucleoside analogs and pharmaceuticals.

How is 2'-Deoxy-N-[(dimethylamino)methylene]guanosine (CAS: 17331-13-4) typically synthesized?

2'-Deoxy-N-[(dimethylamino)methylene]guanosine is typically synthesized through a multistep process involving the methylation of guanine followed by the installation of the 2'-deoxyribose moiety. Common reagents include dimethylamine and dimethyl sulfate. The overall yield is moderate to good, and the reaction is carried out under mild conditions to ensure selectivity.

What industries use 2'-Deoxy-N-[(dimethylamino)methylene]guanosine (CAS: 17331-13-4)?

2'-Deoxy-N-[(dimethylamino)methylene]guanosine is primarily used in the pharmaceutical industry for the development of nucleoside analogs with potential antiviral and antitumor activities. It is also used in research for the synthesis of other nucleosides and in the field of molecular biology.

What precautions should be taken when handling 2'-Deoxy-N-[(dimethylamino)methylene]guanosine (CAS: 17331-13-4)?

When handling 2'-Deoxy-N-[(dimethylamino)methylene]guanosine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up promptly with care to avoid inhalation or skin contact. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.