2'-Deoxy-N-[(dimethylamino)methylene]guanosine(CAS: 17331-13-4)

2'-Deoxy-N-[(dimethylamino)methylene]guanosine is a solid compound with a molecular weight of approximately 371.22 g/mol. It has poor water solubility and good solubility in organic solvents like DMSO. This compound is known for its chemical stability under neutral and slightly acidic conditions but can react with strong acids or bases. It is used in the synthesis of nucleoside analogs and pharmaceuticals.

2'-Deoxy-N-[(dimethylamino)methylene]guanosine is typically synthesized through a multistep process involving the methylation of guanine followed by the installation of the 2'-deoxyribose moiety. Common reagents include dimethylamine and dimethyl sulfate. The overall yield is moderate to good, and the reaction is carried out under mild conditions to ensure selectivity.

2'-Deoxy-N-[(dimethylamino)methylene]guanosine is primarily used in the pharmaceutical industry for the development of nucleoside analogs with potential antiviral and antitumor activities. It is also used in research for the synthesis of other nucleosides and in the field of molecular biology.

When handling 2'-Deoxy-N-[(dimethylamino)methylene]guanosine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up promptly with care to avoid inhalation or skin contact. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.