Avapritinib | CAS No. 1703793-34-3

Avapritinib

Basic Information

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CAS Number

1703793-34-3

Molecular Formula

C26H27FN10

Molecular Weight

498.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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Cn1cc(cn1)c2cc3c(ncnn3c2)N4CCN(CC4)c5ncc(cn5)[C@@](C)(N)c6ccc(F)cc6

InChI

InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1

InChIKey

DWYRIWUZIJHQKQ-SANMLTNESA-N

LogP

2.6077000000000004

Topological Polar Surface Area

106.29 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

752

Synonyms & References

English

BLU-285
(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethanamine
Avapritinib
BLU285
513P80B4YJ
(1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine
(S)-1-(4-Fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine
Ayvakit
Avapritinib [INN]
Ayvakit (TN)
Avapritinib (USAN/INN)
GTPL10368
s8553

MDL Number

MFCD31544325

FAQ

What is Avapritinib (CAS: 1703793-34-3)?

Avapritinib is a selective inhibitor of the PDGFRA D842V mutation, used in the treatment of gastrointestinal stromal tumor (GIST) with the PDGFRA D842V mutation and systemic mastocytosis (SM) with one or more mutations in the KIT gene.

What are the main uses of Avapritinib (CAS: 1703793-34-3)?

Avapritinib is primarily used for treating patients with unresectable or metastatic GIST harboring the PDGFRA D842V mutation and systemic mastocytosis with one or more KIT mutations. It is also being studied for other potential uses in oncology.

Is Avapritinib (CAS: 1703793-34-3) safe?

Avapritinib is generally considered safe when used as directed. However, it can cause side effects such as diarrhea, nausea, and fatigue. Patients should be monitored for these effects and other potential side effects. Always follow the prescribed dosage and medical advice.

How should Avapritinib (CAS: 1703793-34-3) be stored?

Avapritinib should be stored at room temperature (15-30°C) and protected from light. It should be kept in a tightly closed container and away from moisture and heat to maintain its efficacy and stability.