2-Thiophenesulfonyl chloride

Basic Information

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CAS Number

16629-19-9

Molecular Formula

C4H3ClO2S2

Molecular Weight

182.65 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

30-32 °C

Boiling Point

130-132 °C/14 mmHg

Water Solubility

Reacts with water.

Refractive Index

1.5722-1.5742

SMILES

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C1=CSC(=C1)S(=O)(=O)Cl

InChI

InChI=1S/C4H3ClO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H

InChIKey

VNNLHYZDXIBHKZ-UHFFFAOYSA-N

LogP

1.6756

Topological Polar Surface Area

34.14 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

181

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

AS-17542
thiophene-2-sulfonylchloride
2-Thienylsulfonyl chloride
DTXSID9066093
AKOS000119665
thiophene-2-sulphonic acid chloride
Thiophene-2-sulphonyl chloride
EINECS 240-677-1
AM20080472
SCHEMBL15907
BCP26543
thiophen-2-sulfonyl chloride
2-thiophen-sulfonyl chloride
2-thiophene sulfonyl chloride
2-Thienylsulfonylchloride
2-thiophenesulphonylchloride
2-Thiophenesulfonyl chloride, 96%
Thiophene-2-sulfonyl chloride
W-107927
2-Thiophenesulfonyl chloride
thiophene sulfonyl chloride
MFCD00005426
2-thiophenyl-sulfonyl chloride
InChI=1/C4H3ClO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3
EN300-18935
2-thiophensulfonyl chloride
A15283
thiophene 2-sulfonyl chloride
2-thiophen-sulphonyl chloride
CS-W017078
T2122

MDL Number

MFCD00005426

Customs Code

29349990

FAQ

What are the physical and chemical properties of 2-Thiophenesulfonyl chloride (CAS: 16629-19-9)?

2-Thiophenesulfonyl chloride is a white or off-white crystalline solid. It has a molecular weight of 216.08 g/mol and a melting point around 115-116°C. It is slightly soluble in water but has good solubility in organic solvents such as ethanol and dichloromethane. It is highly reactive, especially with amines and thiols, and can form sulfonamides and thiolsulfonamides, respectively.

How is 2-Thiophenesulfonyl chloride (CAS: 16629-19-9) typically synthesized?

2-Thiophenesulfonyl chloride is typically synthesized by the chlorosulfonylation of thiophene using thionyl chloride as the reagent. The reaction is performed under anhydrous conditions to avoid hydrolysis. Catalysts such as aluminum chloride or aluminum bromide may be used to improve the yield and selectivity of the product.

What industries use 2-Thiophenesulfonyl chloride (CAS: 16629-19-9)?

2-Thiophenesulfonyl chloride finds applications in various industries, including pharmaceuticals, where it is used as an intermediate in drug synthesis. It is also used in the synthesis of certain dyes and pigments, in the production of polymeric materials, and in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 2-Thiophenesulfonyl chloride (CAS: 16629-19-9)?

Handling 2-Thiophenesulfonyl chloride requires careful attention due to its high reactivity and potential for skin and eye irritation. It is recommended to use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. If a spill occurs, it should be cleaned up immediately with care, and appropriate safety data sheets (SDS) should be consulted for specific cleanup procedures.