Everolimus | CAS No. 159351-69-6

Everolimus

Basic Information

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CAS Number

159351-69-6

Molecular Formula

C53H83NO14

Molecular Weight

958.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

No data available

Melting Point

Boiling Point

998.7±75.0 °C(Predicted)

Density

1.18±0.1 g/cm3(Predicted)

Water Solubility

Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.

Flash Point

2℃

Refractive Index

1.55

SMILES

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OCCO[C@@H]1CC[C@H](C[C@H]1OC)C[C@H]([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H](CC[C@H]2C)C[C@H](OC)C(=CC=CC=C[C@H](C[C@H](C(=O)[C@@H]([C@@H](C(=C[C@H](C(=O)C1)C)C)O)OC)C)C)C)C

InChI

InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

InChIKey

HKVAMNSJSFKALM-DHGBBOBXSA-N

LogP

6.1972000000000085

pKa

10.40±0.70(Predicted)

Topological Polar Surface Area

204.65999999999997 Å²

Hydrogen Bond Donor/Acceptor

3 / 15

Complexity

1810

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Stability

Hygroscopic

Synonyms & References

English

Everolimus
42-O-(2-Hydroxyethyl)-rapamycin
Certica
RAD-001
SDZRAD
Rapamycin, 42-O-(2-hydroxyethyl)-
Certican
CERTICAN(R)
Everolimus (RAD001)
Everolimus (RAD001, SDZ-RAD, Afinitor®, Certican®, and Zortress®)
Everolimus solution
&nbsp
Afinitor
RAD001
SDZ-RAD
Zortress
EVEROLIMUS(WITHOUT BHT)
40-O-(2-Hydroxyethyl)rapamycin
42-O-(2-Hydroxyethyl)rapamycin
CERTICAN®
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine,rapamycin deriv.
42-O-(2-Hydroxy)ethylrapamycin
RAD
XIENCE V
EveroliMus API
Everolimus(RAD001)
Votubia
40-O-(2-hydroxyethyl)-rapamycin
Afinitor Disperz
RAD 001
9HW64Q8G6G

MDL Number

MFCD00929329

Customs Code

29349990

FAQ

What is Everolimus (CAS: 159351-69-6)?

Everolimus is a chemical compound with the CAS number 159351-69-6. It is an mTOR inhibitor, a type of immunosuppressant drug, and is used to prevent organ rejection after transplantation. Its chemical formula is C29H36N2O6S, and it is a white to off-white solid with good solubility in certain organic solvents.

What are the main uses of Everolimus (CAS: 159351-69-6)?

Everolimus is primarily used in pharmaceutical applications as an immunosuppressant to reduce the risk of organ rejection. It is also used in cancer treatment to inhibit tumor growth and in research for studying mTOR signaling pathways. Its CAS number 159351-69-6 identifies it as a key compound in drug development and therapeutic use.

Is Everolimus (CAS: 159351-69-6) safe?

Everolimus is generally considered safe when used as directed, but it can have side effects such as diarrhea, mouth sores, and increased infection risk. Proper handling and adherence to safety guidelines are essential. It is regulated by safety standards to ensure safe use in medical and research settings.

How should Everolimus (CAS: 159351-69-6) be stored?

Everolimus should be stored in a cool, dry place away from light. It is typically kept in a sealed container at a temperature between 15°C to 25°C. Proper storage conditions help maintain its chemical stability and effectiveness over time.