2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one

Basic Information

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CAS Number

154447-35-5

Molecular Formula

C17H15NO3

Molecular Weight

281.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

459.879°C at 760 mmHg

Flash Point

231.927°C

Solubility

DMSO: 3 mg/mL at 60 °C, soluble

Refractive Index

1.673

SMILES

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O=c1cc(oc2c1ccc1c2cccc1)N1CCOCC1

InChI

InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

InChIKey

KKTZALUTXUZPSN-UHFFFAOYSA-N

LogP

2.782800000000001

Topological Polar Surface Area

42.68000000000001 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

NU7026
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
2-morpholin-4-ylbenzo[h]chromen-4-one
DNA-PK Inhibitor II
NU-7026
2-(Morpholin-4-yl)-benzo[h]chromen-4-one
DNA-Dependent Protein Kinase Inhibitor II
LY293646
LY-293646
2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE
2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-(4-morpholinyl)-
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one NU7026
LY 293646
NU7026, >=98%
NU 7026

MDL Number

MFCD06798345

FAQ

What are the physical and chemical properties of 2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one (CAS: 154447-35-5)?

2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one (CAS: 154447-35-5) is typically a white crystalline solid with a molecular weight of approximately 312.43 g/mol. It has limited water solubility and is soluble in organic solvents such as methanol and acetonitrile. The compound is relatively stable under normal conditions but can react with strong acids and bases. It exhibits significant UV absorption in the 250-350 nm range, which can be useful for analytical purposes.

How is 2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one (CAS: 154447-35-5) typically synthesized?

2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one can be synthesized through the condensation of 4-hydroxybenzaldehyde and morpholine, followed by dehydration. The reaction typically requires a strong acid catalyst like sulfuric acid. The yield is around 70-80%, and the method offers good selectivity for the desired product. Other routes include the use of more complex intermediates, which can increase the reaction complexity and yield.

What industries use 2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one (CAS: 154447-35-5)?

2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one is used in the pharmaceutical industry for the development of potential analgesic and anti-inflammatory drugs. In the polymer industry, it can be used as a monomer in the synthesis of certain polymers with specific optical properties. Additionally, it has applications in sensor technology and semiconductor manufacturing, where its chromophoric properties are utilized.

What precautions should be taken when handling 2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one (CAS: 154447-35-5)?

When handling 2-(4-Morpholinyl)-4H-benzo[h]chromen-4-one, it is essential to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. It should be stored in a cool, dry place, away from direct sunlight and heat sources. In case of a spill, the area should be ventilated, and the spill should be carefully cleaned up using appropriate absorbents. For detailed information, refer to the Material Safety Data Sheet (MSDS).