1-(4-Hydroxyphenyl)thiourea

Basic Information

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CAS Number

1520-27-0

Molecular Formula

C7H8N2OS

Molecular Weight

168.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

214 °C

Boiling Point

341.5°Cat760mmHg

Density

1.45

Flash Point

160.3°C

Refractive Index

1.777

SMILES

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C1=CC(=CC=C1NC(=S)N)O

InChI

InChI=1S/C7H8N2OS/c8-7(11)9-5-1-3-6(10)4-2-5/h1-4,10H,(H3,8,9,11)

InChIKey

QICKOOCQSYZYQB-UHFFFAOYSA-N

LogP

1.0477

Topological Polar Surface Area

58.28 Å²

Hydrogen Bond Donor/Acceptor

4 / 3

Complexity

143

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

1-(4-Hydroxyphenyl)-2-thiourea
WLN: SUYZMR DQ
1-(4-hydroxyphenyl)thiourea
THIOUREA, N-(4-HYDROXYPHENYL)-
4-13-00-01132 (Beilstein Handbook Reference)
BRN 1102429
BB 0245266
1520-27-0
(4-Hydroxyphenyl)thiourea
NSC 43638
Thiourea, (4-hydroxyphenyl)-
AKOS000108404
Urea, 1-(p-hydroxyphenyl)-2-thio-
NSC43638
SCHEMBL1822006
N-(4-Hydroxyphenyl)Thiourea
BAA52027
CHEMBL1088500
FT-0605728
USAF B-75
(4-Hydroxy-phenyl)-thiourea
4-hydroxyphenylthiourea
p-Oxyphenylthioharnstoff
Thiourea,N-(4-hydroxyphenyl)-
MFCD00041186
4-[(Aminothioxomethyl)amino]phenol
4-THIOUREIDOPHENOL
A809245
AB7339
U97KKG63Z2
DTXSID80164932

MDL Number

MFCD00041186

Customs Code

2930909090

FAQ

What are the physical and chemical properties of 1-(4-Hydroxyphenyl)thiourea (CAS: 1520-27-0)?

1-(4-Hydroxyphenyl)thiourea is a crystalline compound with a molecular weight of approximately 197.22 g/mol. It has a solubility of about 1.4 g/100 mL in water at 25°C. Chemically, it is reactive towards reducing agents and certain nucleophiles. This compound is used in the preparation of other thiourea derivatives and in some pharmaceutical applications.

How is 1-(4-Hydroxyphenyl)thiourea (CAS: 1520-27-0) typically synthesized?

1-(4-Hydroxyphenyl)thiourea is typically synthesized via the condensation of 4-hydroxyaniline with thiourea. The reaction is usually carried out in an aqueous medium, with a yield of around 80-85%. Commonly, mild heating and the use of a base catalyst like sodium hydroxide are employed for better selectivity and yield.

What industries use 1-(4-Hydroxyphenyl)thiourea (CAS: 1520-27-0)?

1-(4-Hydroxyphenyl)thiourea (CAS: 1520-27-0) is primarily used in the pharmaceutical industry for the preparation of certain drugs. It also finds applications in the polymer industry as a stabilizer and in the production of sensors for detecting various chemical species. In the semiconductor industry, it is used as a precursor in the synthesis of other materials.

What precautions should be taken when handling 1-(4-Hydroxyphenyl)thiourea (CAS: 1520-27-0)?

When handling 1-(4-Hydroxyphenyl)thiourea (CAS: 1520-27-0), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate safety measures and according to the Material Safety Data Sheet (MSDS). Always consult the SDS for detailed safety information.