2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione | CAS No. 1496997-41-1
2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione
Basic Information
CAS Number
1496997-41-1
Molecular Formula
C13H8F2N2O4
Molecular Weight
294.21 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- Thalidomide-5,6-F
- 2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione
- 2-(2,6-dioxopiperidin-3-yl)-5,6-difluoro-2,3-dihydro-1H-isoindole-1,3-dione
- 2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindole-1,3-dione
- ZB1849
- AT17986
- SY289994
MDL Number
MFCD32853274
FAQ
What are the physical and chemical properties of 2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione (CAS: 1496997-41-1)?
2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione is a crystalline solid with a molecular weight of approximately 338.06 g/mol. It has a low solubility in water but is soluble in organic solvents. Chemically, it is stable under normal conditions but reacts with strong bases to form salts. It is also susceptible to hydrolysis in the presence of moisture.
How is 2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione (CAS: 1496997-41-1) typically synthesized?
2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione is synthesized via the amidation of 2,6-difluoro-1H-isoindole-1,3(2H)-dione with 2,6-dicarboxylic acid piperidine, using an appropriate base as the catalyst. The reaction is conducted in anhydrous conditions to prevent hydrolysis. The yield is typically around 85% with high selectivity.
What industries use 2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione (CAS: 1496997-41-1)?
This compound is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It is also utilized in the polymer industry for the development of novel materials with specific properties. Additionally, it has applications in the production of sensors and semiconductors due to its unique chemical structure.
What precautions should be taken when handling 2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione (CAS: 1496997-41-1)?
Proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn when handling this compound. It should be stored in a cool, dry place away from moisture and strong bases. In case of a spill, it should be cleaned up using appropriate absorbents and the area should be fumigated with a fume hood. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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