1-Ethoxy-2,2-difluoroethanol

Basic Information

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CAS Number

148992-43-2

Molecular Formula

C4H8F2O2

Molecular Weight

126.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Refractive Index

1.3660-1.3720

SMILES

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CCOC(C(F)F)O

InChI

InChI=1S/C4H8F2O2/c1-2-8-4(7)3(5)6/h3-4,7H,2H2,1H3

InChIKey

WEEOMNFWRCDRJI-UHFFFAOYSA-N

LogP

0.6064

Topological Polar Surface Area

29.46 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

Safety Information

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GHS Hazard Pictograms

H226

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

Hazard Class

Class 3 Class 3

Synonyms & References

English

J-008539
CS-0179771
EN300-64372
MFCD01321160
148992-43-2
Ethanol, 1-ethoxy-2,2-difluoro-
difluroacetaldehyde ethyl hemiacetal
1-Ethoxy-2,2-difluoroethanol, tech grade
1-ethoxy-2,2-difluoroethan-1-ol
C4H8F2O2
DTXSID40374237
Difluoroacetaldehyde Ethyl Hemiacetal
1-Ethoxy-2,2-difluoroethanol
D2523
AS-48264
AM803241
SCHEMBL635097
FT-0691024
difluoroacetaldehyde ethylhemiacetal
F30106
AKOS015838744
SY007828
Difluoroacetaldehyde ethyl hemiacetal
EOS-61532
1-Ethoxy-2,2-difluoro-ethanol
WEEOMNFWRCDRJI-UHFFFAOYSA-N
Ethanol,1-ethoxy-2,2-difluoro-
7426AA
STL557774
BBL103964
AB1010791

MDL Number

MFCD01321160

FAQ

What are the physical and chemical properties of 1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2)?

1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2) is a colorless, flammable liquid with a molecular weight of approximately 120.12 g/mol. It has a low boiling point of 85-87°C and a high vapor pressure. Soluble in water and organic solvents, it exhibits good reactivity towards nucleophiles and electrophiles. It is often used in organic synthesis due to its functional groups.

How is 1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2) typically synthesized?

1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2) can be synthesized through a dehydrofluorination reaction of ethyl 2,2-difluoroacetate with sodium ethoxide. The reaction involves a palladium catalyst and typically yields a product with >95% purity. The process is conducted under mild conditions to maintain the integrity of the functional groups.

What industries use 1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2)?

1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2) is primarily used in the pharmaceutical, polymer, and chemical industries. It serves as a valuable intermediate in the synthesis of various compounds, particularly in the field of drug discovery and development. Its unique structure also makes it applicable in the production of functional polymers and as a reagent in analytical chemistry.

What precautions should be taken when handling 1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2)?

When handling 1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Ensure that the work is conducted in a well-ventilated area or a fume hood. Spills should be carefully cleaned up using appropriate absorbent materials. The substance is flammable and requires storage in a cool, dry place away from heat sources and oxidizers. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.