1-Ethoxy-2,2-difluoroethanol(CAS: 148992-43-2)

1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2) is a colorless, flammable liquid with a molecular weight of approximately 120.12 g/mol. It has a low boiling point of 85-87°C and a high vapor pressure. Soluble in water and organic solvents, it exhibits good reactivity towards nucleophiles and electrophiles. It is often used in organic synthesis due to its functional groups.

1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2) can be synthesized through a dehydrofluorination reaction of ethyl 2,2-difluoroacetate with sodium ethoxide. The reaction involves a palladium catalyst and typically yields a product with >95% purity. The process is conducted under mild conditions to maintain the integrity of the functional groups.

1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2) is primarily used in the pharmaceutical, polymer, and chemical industries. It serves as a valuable intermediate in the synthesis of various compounds, particularly in the field of drug discovery and development. Its unique structure also makes it applicable in the production of functional polymers and as a reagent in analytical chemistry.

When handling 1-Ethoxy-2,2-difluoroethanol (CAS: 148992-43-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Ensure that the work is conducted in a well-ventilated area or a fume hood. Spills should be carefully cleaned up using appropriate absorbent materials. The substance is flammable and requires storage in a cool, dry place away from heat sources and oxidizers. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.