5-(4-Bromophenyl)-4,6-dichloropyrimidine

Basic Information

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CAS Number

146533-41-7

Molecular Formula

C10H5BrCl2N2

Molecular Weight

303.97 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

98.0 to 102.0 deg-C

Boiling Point

368.7±42.0°C at 760 mmHg

SMILES

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Clc1ncnc(c1c1ccc(cc1)Br)Cl

InChI

InChI=1S/C10H5BrCl2N2/c11-7-3-1-6(2-4-7)8-9(12)14-5-15-10(8)13/h1-5H

InChIKey

WEEFLZORZXLIJE-UHFFFAOYSA-N

LogP

4.212900000000001

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

5-(4-broMophenyl)-4,6-dichloropyriMidine
PyriMidine, 5-(4-broMophenyl)-4,6-dichloro-
potassiuM (N-propylsulfaMoyl)aMide
5-(4-Bromophenyl)-4,6-dichloro-1,3-diazine
4,6-Dichloro-5-(4-bromophenyl)pyrimidine
(4-broMophenyl)-4,6-dichloroPyriMidine
5-(4-Bromophenyl)-4,6-dichloro-Pyrimidin
5-(4-broMophenyl)-4
Pyrimidine, 5-(4-bromophenyl)-4,6-dichloro
QC-9668
Macitentan Intermediate 1
5-(4-bromophenyl)-4,6-dichloropyrimidine

MDL Number

MFCD13151897

FAQ

What is 5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS: 146533-41-7)?

5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS: 146533-41-7) is an organic compound with the chemical formula C10H6BrCl2N2. It is a pyrimidine derivative featuring a 4-bromophenyl group at the 5-position and two chlorine atoms at the 4 and 6 positions. This compound is typically a solid with low solubility in water and is characterized by its halogenated structure, making it valuable in chemical synthesis and research applications.

What are the main uses of 5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS: 146533-41-7)?

5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS: 146533-41-7) is primarily used in pharmaceutical research as an intermediate for drug development, particularly in compounds targeting metabolic disorders. It also finds applications in agrochemicals and material science due to its reactivity. Its unique structure makes it a key component in synthesizing bioactive molecules and organic compounds for industrial and scientific purposes.

Is 5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS: 146533-41-7) safe?

5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS: 146533-41-7) requires careful handling due to potential toxicity. It is classified as a hazardous chemical, with safety measures including use of personal protective equipment (PPE) and working in well-ventilated areas. Long-term exposure may pose health risks, so adherence to safety standards and proper disposal protocols is essential for minimizing harm.

How should 5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS: 146533-41-7) be stored?

5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS: 146533-41-7) should be stored in a cool, dry, and dark place in a sealed container to prevent moisture and light exposure. It is stable under standard conditions but requires airtight storage to maintain chemical integrity. Avoid contact with incompatible substances and ensure storage areas are properly labeled for safety and compliance.