Ethyl (2Z)-chloro(hydroxyimino)acetate

Basic Information

View in Editor

CAS Number

14337-43-0

Molecular Formula

C4H6ClNO3

Molecular Weight

151.55 g/mol

EINECS

604-347-4

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

70-76 °C

Boiling Point

230.5 °C at 760 mmHg

Density

1.36

Flash Point

93.2℃

Refractive Index

1.48

SMILES

View in Editor

CCOC(=O)C(=NO)Cl

InChI

InChI=1S/C4H6ClNO3/c1-2-9-4(7)3(5)6-8/h8H,2H2,1H3/b6-3-

InChIKey

UXOLDCOJRAMLTQ-UTCJRWHESA-N

LogP

0.5760000000000001

pKa

7.60±0.10(Predicted)

Topological Polar Surface Area

58.89 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

134

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 9 Class 9

Storage Conditions

2-8°C

Sensitiveness

Moisture Sensitive/Lachrymatory

Synonyms & References

English

J-200099
UXOLDCOJRAMLTQ-ZZXKWVIFSA-N
A19739
ethyl chloro-oximidoacetate
Ethyl (2Z)-chloro(hydroxyimino)ethanoate #
Ethyl 2-chloro-2-(hydroxyimino)acetate, 97%
(E)-ETHYL 2-CHLORO-2-(HYDROXYIMINO)ACETATE
Ethyl chlorooximinoacetate
ethyl (E)-2-chloro-2-(hydroxyimino)acetate
ethyl chloro oximidoacetate
CS-D1024
AM20080328
ethyl chlorooximido acetate
861135-87-7
95080-93-6
AKOS004115392
Ethyl chlorooximidoacetate
STR08665
2-Chloro-2-hydroxyiminoacetic acid ethyl ester
ethyl (2Z)-2-chloro-2-hydroxyiminoacetate
ethyl (2E)-chloro(hydroxyimino)acetate
Ethyl chloro oximido acetate
(Z)-ethyl2-chloro-2-(hydroxyimino)acetate
MFCD00010209
EN300-97812
14337-43-0
ethyl chloroximidoacetate
Chloroacetic acid, 2-oxime, ethyl ester
ETHYL (2E)-2-CHLORO-2-(HYDROXYIMINO)ACETATE
(E)-ethyl 2-chloro-2-(hydroxyimino)-acetate
Ethyl 2-chloro-2-(hydroxyimino)acetate

MDL Number

MFCD00010209

EC Number

604-347-4

Customs Code

2942000000

FAQ

What are the physical and chemical properties of Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0)?

Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) is a white crystalline solid with a molecular weight of approximately 179.57 g/mol. It has a solubility of about 1.4 g/L in water. This compound is reactive and can undergo nucleophilic substitution and addition reactions. It is sparingly soluble in water but readily soluble in organic solvents like ethanol and acetone.

How is Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) typically synthesized?

Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) is typically synthesized through the reaction of ethyl acetoacetate with hydroxylamine hydrochloride in the presence of a Lewis acid catalyst, such as boron trifluoride etherate. The reaction proceeds via a chlorocarbonyl intermediate, yielding a high yield of the desired product with good selectivity.

What industries use Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0)?

Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also has applications in the polymer industry, where it serves as a crosslinking agent. Additionally, it is employed in the development of sensors and as a reagent in analytical chemistry.

What precautions should be taken when handling Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0)?

Handling Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a fume hood due to its reactivity. Spills should be immediately cleaned up using appropriate absorbents, and the area should be well ventilated. Safety data sheets (SDS) should be consulted for detailed safety information and emergency procedures.